Detailed information NTG0047615

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LCGL_RS11790
• Genome accession: NC_017490
• Coordinates: 358496..360946 (+)
• Length: 816 a.a.
• NCBI ID: WP_014024302.1
• Uniprot ID: F9VBW2
• Organism: Lactococcus garvieae Lg2
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 353496..365946

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LCGL_RS11765 (LCGL_0348)	-	354404..354916 (+)	513	WP_003134000.1	adenine phosphoribosyltransferase	-
LCGL_RS11770 (LCGL_0349)	rpoE	355054..355614 (+)	561	WP_003134001.1	DNA-directed RNA polymerase subunit delta	-
LCGL_RS11775 (LCGL_0350)	mltG	355720..357435 (+)	1716	WP_014024301.1	endolytic transglycosylase MltG	-
LCGL_RS11780 (LCGL_0351)	greA	357460..357933 (+)	474	WP_003134005.1	transcription elongation factor GreA	-
LCGL_RS11785 (LCGL_0352)	-	358054..358506 (+)	453	WP_003134006.1	CtsR family transcriptional regulator	-
LCGL_RS11790 (LCGL_0353)	clpC	358496..360946 (+)	2451	WP_014024302.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
LCGL_RS11795 (LCGL_0354)	hpf	361070..361627 (+)	558	WP_014024303.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
LCGL_RS11800 (LCGL_0355)	pflB	361875..364208 (+)	2334	WP_003134012.1	formate C-acetyltransferase	-
LCGL_RS11805 (LCGL_0356)	coaE	364440..365045 (+)	606	WP_014024304.1	dephospho-CoA kinase	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 91147.38 Da
• Isoelectric Point: 6.1751

>NTDB_id=47615 LCGL_RS11790 WP_014024302.1 358496..360946(+) (clpC) [Lactococcus garvieae Lg2]
MKFNEKDFTPQVVRVLEKSVDYAHKFNYAWVESSHLLAALAEVPASLAFTLLNSEKIDLEEMLIDIEDFSSQVKTKKSDI
KLSPRVETIIEQARALAQNNDKNRIGTEHLLYMLLANEASFAGQLLREQNINIVNLRKKLEQKAYLRVPERRKAVTPASK
RNLSGKVSETTTTPTLDTVSTDLTKAAREGKLDPMIGREREVERLIHILSRRTKNNPVLVGEPGVGKSAIIEGFATRVAA
GNVPVGLRGSRIMALNMAMVVAGTKFRGEFEDRLTAIVDEVTHDKDVIVFIDELHTIIGAGGGMDSVNDASNILKPALAR
GEFQLIGATTYQEYQKYIEKDEALERRFARVNVEEPSEKETVAILQGLKEKFEAYHAVKFEEGALERAVSLSNRYMPSRR
LPDKAIDLLDEAAAKVKITSKTNYTKLDELKAELKAEELKLQQAVVALDIVEAQGIEKDIERLTHKIDNFTVSENDNPLV
EESDIYAVVSNLTGIPLQQMTRTESERLINLEKELHKRVVGQEEAISAVSRAIRRARSGIADTRRPLGSFMFLGPTGVGK
TELAKALAESVFGSEENMIRVDMSEFMEKFSTSRLIGAPPGYVGYDEGGQLTEQVRNKPYSVILLDEVEKAHPDIFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATAIRDDKTVGFGAKSISTDYAAMKARIMEELKKQYRPEFLNRIDETIVF
HSLTEKEIEQVVKIMSKSLVSRLKDQNITVKFTPAALKVIADKGFDPEYGARPLRKALQREIEDTLSEQLLAGEIHPGDT
ISIGSSNKKIRISVID

Nucleotide

• Length: 2451 bp

>NTDB_id=47615 LCGL_RS11790 WP_014024302.1 358496..360946(+) (clpC) [Lactococcus garvieae Lg2]
ATGAAATTTAATGAAAAGGACTTTACACCACAAGTCGTTAGAGTGCTCGAGAAGTCTGTCGACTATGCGCATAAGTTTAA
CTACGCTTGGGTAGAAAGCTCGCACCTATTGGCTGCCTTGGCTGAGGTTCCGGCTTCATTGGCATTTACGCTACTTAATT
CAGAAAAGATTGATTTGGAAGAGATGTTAATCGACATCGAAGATTTTTCAAGTCAAGTAAAGACAAAAAAATCAGACATA
AAGCTTAGCCCAAGAGTCGAAACGATTATTGAGCAAGCCCGAGCATTGGCTCAAAATAACGATAAAAACCGTATTGGAAC
AGAGCATCTCTTGTATATGCTGTTGGCAAATGAAGCCAGCTTTGCAGGACAACTTTTACGTGAGCAAAACATTAATATCG
TTAACCTCCGTAAAAAGTTAGAGCAAAAAGCATATTTACGAGTGCCAGAACGCCGTAAAGCGGTGACCCCAGCCTCAAAA
AGAAACCTGTCGGGGAAGGTGTCCGAAACAACAACAACACCTACTTTAGATACAGTCTCGACAGATTTGACAAAAGCAGC
GCGTGAAGGAAAGCTTGATCCAATGATTGGGAGAGAGCGTGAAGTCGAACGTCTTATCCATATTTTGAGTCGCCGCACAA
AGAATAATCCCGTTCTTGTTGGTGAACCAGGCGTTGGTAAGTCAGCGATTATTGAAGGCTTTGCAACACGTGTGGCTGCA
GGGAATGTTCCTGTAGGTTTACGCGGCAGTCGTATCATGGCCTTGAATATGGCGATGGTCGTAGCGGGGACGAAGTTCCG
TGGCGAATTTGAAGATCGTTTGACAGCTATTGTGGATGAAGTGACACATGATAAAGATGTTATCGTCTTTATCGATGAAC
TCCATACTATTATTGGTGCTGGGGGAGGCATGGACTCTGTCAATGATGCCTCAAACATTTTAAAACCCGCATTAGCACGT
GGCGAGTTTCAACTTATTGGTGCTACTACTTATCAAGAATATCAAAAATATATTGAAAAAGATGAAGCTCTGGAGCGTCG
TTTTGCCCGTGTCAATGTCGAAGAACCCTCAGAAAAAGAAACGGTTGCGATTTTACAAGGCTTGAAAGAAAAATTTGAAG
CTTACCATGCGGTTAAATTTGAAGAGGGGGCTTTGGAGCGTGCCGTTAGCTTGAGTAATCGCTACATGCCAAGTCGTCGT
CTGCCAGACAAAGCCATTGATCTTCTTGATGAAGCAGCGGCCAAAGTTAAAATCACGAGTAAAACAAATTACACCAAGCT
AGACGAGTTAAAAGCAGAATTAAAAGCGGAAGAGCTGAAATTACAACAAGCAGTTGTTGCTCTTGATATTGTTGAAGCAC
AAGGAATTGAAAAAGATATTGAAAGATTAACACACAAAATTGATAATTTTACAGTATCGGAAAATGATAATCCTTTGGTC
GAAGAAAGCGATATTTATGCTGTTGTTTCTAACCTTACAGGAATTCCGCTCCAACAAATGACGAGAACAGAAAGTGAACG
TCTGATTAACTTAGAAAAAGAGTTACATAAACGTGTGGTCGGACAGGAAGAAGCGATTTCGGCTGTTTCTCGTGCTATAA
GACGTGCGCGTTCAGGTATTGCTGATACGAGACGTCCTCTGGGCTCATTTATGTTCCTTGGTCCGACAGGGGTGGGGAAA
ACAGAGCTTGCTAAAGCTTTAGCGGAAAGTGTCTTTGGGAGTGAAGAGAACATGATTCGCGTAGACATGAGTGAATTTAT
GGAAAAATTCTCGACATCGCGTCTTATCGGAGCACCTCCAGGGTATGTAGGTTACGACGAAGGGGGACAATTGACAGAGC
AAGTCCGTAATAAGCCTTATTCTGTTATTCTCCTTGATGAAGTTGAAAAAGCCCATCCTGACATTTTCAATATCATGTTG
CAAATTTTGGATGACGGTTTCGTTACAGATACCAAAGGGCGGAAGGTTGATTTCCGAAATACAATCATCATTATGACATC
TAACTTAGGCGCAACGGCTATTCGTGATGATAAAACGGTTGGTTTTGGGGCTAAATCAATTTCAACAGATTATGCAGCCA
TGAAAGCAAGAATCATGGAAGAACTGAAGAAACAGTACCGTCCAGAATTTCTTAACCGTATTGATGAAACCATCGTTTTC
CATTCACTGACTGAAAAAGAGATTGAACAAGTCGTGAAAATCATGAGTAAATCTCTTGTATCACGTTTGAAAGATCAAAA
TATTACAGTGAAATTTACCCCTGCTGCCTTGAAAGTTATTGCTGATAAAGGATTTGATCCTGAGTATGGTGCACGTCCGT
TGCGTAAAGCGCTACAACGGGAGATTGAAGACACGCTCAGTGAGCAATTGCTTGCAGGCGAAATTCATCCGGGGGATACG
ATTTCGATTGGATCTTCTAATAAAAAGATTAGAATAAGTGTTATTGATTGA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (22-69)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-142)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• AAA lid domain (AAA_lid_9) (357-445)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-349)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-803)

3D structure

• AlphaFold DB: F9VBW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	70.552	99.877	0.705
clpC	Streptococcus thermophilus LMG 18311	49.698	100	0.504
clpC	Streptococcus thermophilus LMD-9	49.698	100	0.504
clpC	Streptococcus pneumoniae TIGR4	49.153	100	0.498
clpC	Streptococcus pneumoniae Rx1	49.031	100	0.496
clpC	Streptococcus pneumoniae D39	49.031	100	0.496
clpC	Streptococcus mutans UA159	47.488	100	0.487
clpC	Bacillus subtilis subsp. subtilis str. 168	48.185	97.917	0.472
clpE	Streptococcus mutans UA159	47.031	78.431	0.369