Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   I6J12_RS01700 Genome accession   NZ_CP068060
Coordinates   345022..345768 (-) Length   248 a.a.
NCBI ID   WP_025271905.1    Uniprot ID   -
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 340022..350768
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS01685 (I6J12_01685) - 342058..343419 (+) 1362 WP_003037280.1 bacteriocin secretion accessory protein -
  I6J12_RS01690 (I6J12_01690) - 343516..343665 (+) 150 WP_003037249.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  I6J12_RS11205 comD/blpH 343710..344531 (-) 822 WP_231847271.1 sensor histidine kinase Regulator
  I6J12_RS01700 (I6J12_01700) comE/blpR 345022..345768 (-) 747 WP_025271905.1 response regulator transcription factor Regulator
  I6J12_RS01705 (I6J12_01705) - 345937..346650 (-) 714 WP_003037434.1 CPBP family intramembrane glutamic endopeptidase -
  I6J12_RS11210 - 346882..346950 (+) 69 Protein_338 bacteriocin class II family protein -
  I6J12_RS11495 - 346980..347105 (+) 126 WP_003037205.1 hypothetical protein -
  I6J12_RS01715 (I6J12_01715) - 347193..347513 (+) 321 WP_003037422.1 hypothetical protein -
  I6J12_RS01720 (I6J12_01720) - 347521..347742 (+) 222 WP_003025422.1 Blp family class II bacteriocin -
  I6J12_RS01725 (I6J12_01725) - 348057..348308 (+) 252 WP_020998893.1 hypothetical protein -
  I6J12_RS01730 (I6J12_01730) - 348706..349026 (+) 321 WP_003037365.1 hypothetical protein -
  I6J12_RS01735 (I6J12_01735) - 349034..349267 (+) 234 WP_003025420.1 garvicin Q family class II bacteriocin -
  I6J12_RS01740 (I6J12_01740) - 349319..349609 (+) 291 WP_003025419.1 bacteriocin immunity protein -
  I6J12_RS01745 (I6J12_01745) - 349761..350081 (+) 321 WP_003025418.1 hypothetical protein -
  I6J12_RS01750 (I6J12_01750) - 350311..350541 (+) 231 WP_003037481.1 bacteriocin class II family protein -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 28702.08 Da        Isoelectric Point: 7.0486

>NTDB_id=458773 I6J12_RS01700 WP_025271905.1 345022..345768(-) (comE/blpR) [Streptococcus anginosus strain FDAARGOS_1155]
MNIFILEDDLTQQYYMETIVEEIIEKHHLQYHHFEVVGKPKQLLEAISEKGSHQIFFLDIEIKTEEEKGLDVAKKIREID
PYAIIVFVTSHSELMPTAFKLQVGALDYLDKSLSKEVFKKRIETALLHTESLTGKGLADDALLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLSDILKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLISRAKIKGLTEA
IAALHRRE

Nucleotide


Download         Length: 747 bp        

>NTDB_id=458773 I6J12_RS01700 WP_025271905.1 345022..345768(-) (comE/blpR) [Streptococcus anginosus strain FDAARGOS_1155]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCATCTTCAATATCATCATTTTGAAGTTGTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGATTTTCTTTTTAGACATTGAAATCAAAACCGAGGAAGAAAAGGGCTTAGACGTTGCTAAAAAGATACGCGAGATAGAT
CCTTATGCCATCATTGTCTTTGTAACCAGTCATTCTGAATTGATGCCGACAGCGTTTAAGCTACAAGTGGGTGCCCTTGA
TTATCTTGACAAATCGTTATCAAAAGAAGTCTTTAAAAAACGGATCGAAACTGCACTGCTACATACTGAAAGCCTAACAG
GTAAAGGGCTGGCAGACGATGCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCATTTAAAGATATTCTTTAT
ATTGAAACTTCCTCTCGTCCTCACCGCTTAGTTCTTTACACACATAGAGGACGTACGGAATTTACTGCTAATCTTTCAGA
TATTTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGCTCCTTTGTTGTTAATCCAGCTAATGTCCATCAAGTGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTATTTCCAGAGCAAAAATAAAAGGGTTAACAGAAGCC
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

50.202

99.597

0.5
  comE/comE1 Streptococcus equinus JB1

44.304

95.565

0.423
  comE Streptococcus pneumoniae Rx1

37.398

99.194

0.371
  comE Streptococcus pneumoniae D39

37.398

99.194

0.371
  comE Streptococcus pneumoniae R6

37.398

99.194

0.371
  comE Streptococcus pneumoniae TIGR4

37.398

99.194

0.371
  comE Streptococcus mitis NCTC 12261

37.398

99.194

0.371
  comE Streptococcus mitis SK321

37.398

99.194

0.371
  comE Streptococcus infantis strain Atu-4

36.992

99.194

0.367