Detailed information NTG0456946

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HUW68_RS10010
• Genome accession: NZ_CP055225
• Coordinates: 2028385..2029428 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus LAC
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2023385..2034428

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HUW68_RS09980 (HUW68_09985)	-	2023803..2025059 (-)	1257	WP_001795438.1	aminopeptidase	-
HUW68_RS09985 (HUW68_09990)	-	2025062..2025262 (-)	201	WP_000180461.1	DUF1128 family protein	-
HUW68_RS09990 (HUW68_09995)	-	2025409..2025873 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HUW68_RS09995 (HUW68_10000)	-	2025880..2026155 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HUW68_RS10000 (HUW68_10005)	-	2026433..2027650 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HUW68_RS10005 (HUW68_10010)	vraR	2027766..2028395 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HUW68_RS10010 (HUW68_10015)	vraS	2028385..2029428 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HUW68_RS10015 (HUW68_10020)	liaF	2029425..2030126 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HUW68_RS10020 (HUW68_10025)	-	2030141..2030527 (-)	387	WP_001110179.1	hypothetical protein	-
HUW68_RS10025 (HUW68_10030)	map	2030744..2031502 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HUW68_RS10030 (HUW68_10035)	-	2032030..2033016 (+)	987	WP_000999713.1	FUSC family protein	-
HUW68_RS10035 (HUW68_10040)	-	2033506..2033919 (-)	414	WP_001549145.1	hypothetical protein	-
HUW68_RS10040 (HUW68_10045)	-	2033948..2034058 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=456946 HUW68_RS10010 WP_001017131.1 2028385..2029428(-) (vraS) [Staphylococcus aureus LAC]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=456946 HUW68_RS10010 WP_001017131.1 2028385..2029428(-) (vraS) [Staphylococcus aureus LAC]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1