Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6H72_RS01625 Genome accession   NZ_CP066055
Coordinates   322612..323958 (+) Length   448 a.a.
NCBI ID   WP_198458165.1    Uniprot ID   -
Organism   Streptococcus constellatus strain FDAARGOS_1015     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 317612..328958
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H72_RS01595 (I6H72_01595) - 318454..319413 (+) 960 WP_198458161.1 ROK family glucokinase -
  I6H72_RS01600 (I6H72_01600) rplS 319563..319910 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  I6H72_RS01610 (I6H72_01610) - 320155..320913 (+) 759 WP_198458162.1 alpha/beta hydrolase -
  I6H72_RS01615 (I6H72_01615) - 321241..321684 (+) 444 WP_198458163.1 hypothetical protein -
  I6H72_RS01620 (I6H72_01620) ciaR 321948..322622 (+) 675 WP_198458164.1 response regulator transcription factor Regulator
  I6H72_RS01625 (I6H72_01625) ciaH 322612..323958 (+) 1347 WP_198458165.1 sensor histidine kinase Regulator
  I6H72_RS01630 (I6H72_01630) - 324390..325838 (-) 1449 WP_198458166.1 alpha-amylase -
  I6H72_RS01635 (I6H72_01635) - 326015..327629 (+) 1615 Protein_324 M20/M25/M40 family metallo-hydrolase -
  I6H72_RS01640 (I6H72_01640) - 327678..328187 (-) 510 WP_198458167.1 DNA topology modulation protein -
  I6H72_RS01645 (I6H72_01645) rpsT 328251..328502 (-) 252 WP_020999623.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50824.62 Da        Isoelectric Point: 10.0178

>NTDB_id=453286 I6H72_RS01625 WP_198458165.1 322612..323958(+) (ciaH) [Streptococcus constellatus strain FDAARGOS_1015]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDHIRQIQVKSNYGREETYRMILFEVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLAQVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMEASESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGMIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=453286 I6H72_RS01625 WP_198458165.1 322612..323958(+) (ciaH) [Streptococcus constellatus strain FDAARGOS_1015]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAACAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCACTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGACAAAGAATTGACAGATAAACCAAATGTTAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAGCCGATTATTACAAGCAATAATTTCTTAGGGCTCAATAAACTTTCCTTTAATAGTAAGCAATTAGACCACA
TTCGTCAGATTCAAGTAAAAAGCAATTATGGTCGAGAAGAAACCTATCGAATGATTTTATTTGAGGTAAAACTGCCTAAT
TTGGAGACCAATGTCAAATACGCAGCGGTTTTTATCAATATCAGTCAATTGGAACAAACTAGTCAAAATCATGAACAGTT
GATTGTGGTGGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTTTATCTTGCACAGGTCAGTGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAAAGTTTTGTCGAAAACGCTAGTCATGAGTTGCGTACACCTCTAGCTGTGTTGCAA
AATCGTTTGGAGACTTTATTTAGAAAGCCAGAAGCTACTATTATGGAAGCCAGTGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAATATGAAAATGTTGACGACAAATTTACTCAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACAACTTTCACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTATGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterProScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.982

100

0.71
  ciaH Streptococcus pneumoniae D39

70.982

100

0.71
  ciaH Streptococcus pneumoniae R6

70.982

100

0.71
  ciaH Streptococcus pneumoniae TIGR4

70.982

100

0.71
  ciaH Streptococcus mutans UA159

55.251

97.768

0.54