Detailed information NTG0426701

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B45_RS05020
• Genome accession: NZ_CP049687
• Coordinates: 975272..976108 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain TSPY515
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 970272..981108

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B45_RS04990 (G8B45_05030)	-	970760..971194 (+)	435	WP_021299262.1	hypothetical protein	-
G8B45_RS04995 (G8B45_05035)	-	971244..972155 (-)	912	WP_011528643.1	diacylglycerol kinase family protein	-
G8B45_RS05000 (G8B45_05040)	-	972272..972922 (-)	651	WP_002984629.1	hemolysin III family protein	-
G8B45_RS05005 (G8B45_05045)	-	972919..973359 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B45_RS05010 (G8B45_05050)	ylqF	973578..974426 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B45_RS05015 (G8B45_05055)	-	974416..975207 (+)	792	WP_011017771.1	ribonuclease HII	-
G8B45_RS05020 (G8B45_05060)	dprA	975272..976108 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B45_RS05025 (G8B45_05065)	topA	976215..978344 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B45_RS05030 (G8B45_05070)	-	978420..979304 (-)	885	Protein_950	LysR family transcriptional regulator	-
G8B45_RS05035 (G8B45_05075)	-	979317..979883 (+)	567	Protein_951	PTS sugar transporter subunit IIC	-
G8B45_RS05040 (G8B45_05080)	-	979898..980890 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=426701 G8B45_RS05020 WP_011017772.1 975272..976108(+) (dprA) [Streptococcus pyogenes strain TSPY515]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=426701 G8B45_RS05020 WP_011017772.1 975272..976108(+) (dprA) [Streptococcus pyogenes strain TSPY515]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367