Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE   Type   Machinery gene
Locus tag   IB935_RS00690 Genome accession   NZ_CP061134
Coordinates   108078..108362 (+) Length   94 a.a.
NCBI ID   WP_011528162.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 103078..113362
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB935_RS00665 (IB935_00665) - 105024..105389 (+) 366 WP_002986560.1 DUF1033 family protein -
  IB935_RS00670 (IB935_00670) comGA 105482..106420 (+) 939 WP_002987773.1 competence type IV pilus ATPase ComGA Machinery gene
  IB935_RS00675 (IB935_00675) comGB 106356..107390 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  IB935_RS00680 (IB935_00680) comGC 107392..107718 (+) 327 WP_011528161.1 competence type IV pilus major pilin ComGC Machinery gene
  IB935_RS00685 (IB935_00685) comGD 107693..108121 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD Machinery gene
  IB935_RS00690 (IB935_00690) comGE 108078..108362 (+) 285 WP_011528162.1 competence type IV pilus minor pilin ComGE Machinery gene
  IB935_RS00695 (IB935_00695) comGF 108355..108789 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  IB935_RS00700 (IB935_00700) comGG 108773..109099 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  IB935_RS00705 (IB935_00705) comGH 109197..110150 (+) 954 WP_021299429.1 class I SAM-dependent methyltransferase Machinery gene
  IB935_RS00710 (IB935_00710) - 110209..111405 (+) 1197 WP_011528164.1 acetate kinase -
  IB935_RS00715 (IB935_00715) - 111592..111900 (+) 309 WP_011528165.1 hypothetical protein -
  IB935_RS00720 (IB935_00720) proC 111983..112753 (-) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -

Sequence

Protein


Download         Length: 94 a.a.        Molecular weight: 10686.65 Da        Isoelectric Point: 8.9043

>NTDB_id=420499 IB935_RS00690 WP_011528162.1 108078..108362(+) (comGE) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
MGIIKKQVKAYIALESMIATGILFSIVILILSSLQQSQAALTYYRKQQEKLNLALMAVQTRTKEMTLNGCHITILRTDRY
ISIHDDEGEVMKIE

Nucleotide


Download         Length: 285 bp        

>NTDB_id=420499 IB935_RS00690 WP_011528162.1 108078..108362(+) (comGE) [Streptococcus pyogenes strain BSAC_bs192 isolate Invasive disease]
GTGGGAATTATCAAAAAACAAGTCAAAGCTTACATAGCCCTTGAAAGTATGATCGCAACAGGCATCCTCTTTAGTATTGT
CATTCTCATCTTAAGCAGTTTACAGCAGAGTCAGGCTGCTCTAACGTACTATCGAAAGCAGCAAGAAAAGCTTAATCTAG
CCTTGATGGCAGTACAAACTAGAACTAAAGAGATGACATTGAATGGTTGTCATATTACTATTTTACGTACGGATAGATAT
ATTAGTATTCACGATGACGAAGGAGAAGTGATGAAGATTGAGTAA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(12-93)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE Lactococcus lactis subsp. cremoris KW2

38.298

100

0.383
  comGE Streptococcus mutans UA140

36.559

98.936

0.362
  comGE Streptococcus mutans UA159

36.559

98.936

0.362