Detailed information NTG0419755

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: IBL27_RS01295
• Genome accession: NZ_CP061071
• Coordinates: 261735..262487 (+)
• Length: 250 a.a.
• NCBI ID: WP_002270252.1
• Uniprot ID: -
• Organism: Streptococcus mutans B04Sm5
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 256735..267487

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBL27_RS01275 (IBL27_01275)	dnaI	257655..258554 (+)	900	WP_002308985.1	primosomal protein DnaI	-
IBL27_RS01280 (IBL27_01280)	der	258567..259877 (+)	1311	WP_002272420.1	ribosome biogenesis GTPase Der	-
IBL27_RS01285 (IBL27_01285)	-	259952..260578 (+)	627	WP_002278266.1	hypothetical protein	-
IBL27_RS01290 (IBL27_01290)	-	260626..261264 (+)	639	WP_002265117.1	VTT domain-containing protein	-
IBL27_RS01295 (IBL27_01295)	comE/blpR	261735..262487 (+)	753	WP_002270252.1	response regulator transcription factor	Regulator
IBL27_RS01300 (IBL27_01300)	comD/blpH	262484..263809 (+)	1326	WP_002308983.1	sensor histidine kinase	Regulator
IBL27_RS01305 (IBL27_01305)	comC/blpC	263978..264109 (-)	132	WP_002268639.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
IBL27_RS01310 (IBL27_01310)	cipB	264376..264606 (+)	231	WP_002309764.1	Blp family class II bacteriocin	Regulator
IBL27_RS01315 (IBL27_01315)	-	264737..265138 (+)	402	WP_002310604.1	hypothetical protein	-
IBL27_RS01320 (IBL27_01320)	-	266518..266937 (+)	420	WP_002263913.1	hypothetical protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29357.76 Da
• Isoelectric Point: 8.2551

>NTDB_id=419755 IBL27_RS01295 WP_002270252.1 261735..262487(+) (comE/blpR) [Streptococcus mutans B04Sm5]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=419755 IBL27_RS01295 WP_002270252.1 261735..262487(+) (comE/blpR) [Streptococcus mutans B04Sm5]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GTCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (153-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	99.2	100	0.992
comE/comE1	Streptococcus equinus JB1	46.888	96.4	0.452
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.551	98	0.368
comE/comE2	Streptococcus gordonii strain NCTC7865	37.551	98	0.368