Detailed information NTG0416518

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: H7786_RS01180
• Genome accession: NZ_CP060649
• Coordinates: 216653..217393 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain TSPY270
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 211653..222393

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7786_RS01165 (H7786_01170)	gltX	212183..213628 (+)	1446	WP_030126476.1	glutamate--tRNA ligase	-
H7786_RS01170 (H7786_01175)	-	214023..215369 (+)	1347	WP_030126477.1	sensor histidine kinase	-
H7786_RS01175 (H7786_01180)	-	215366..216649 (+)	1284	WP_030126478.1	sensor histidine kinase	-
H7786_RS01180 (H7786_01185)	comE/blpR	216653..217393 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
H7786_RS01185 (H7786_01190)	rnpA	217933..218292 (+)	360	WP_030126479.1	ribonuclease P protein component	-
H7786_RS01190 (H7786_01195)	-	218258..219085 (+)	828	WP_030126480.1	YidC/Oxa1 family membrane protein insertase	-
H7786_RS01195 (H7786_01200)	jag	219097..220011 (+)	915	WP_014407283.1	RNA-binding cell elongation regulator Jag/EloR	-
H7786_RS01200 (H7786_01205)	-	220315..220476 (+)	162	WP_006531779.1	hypothetical protein	-
H7786_RS01205 (H7786_01210)	-	220448..221413 (+)	966	WP_228646617.1	replication initiator protein A	-
H7786_RS01210 (H7786_01220)	-	221406..221564 (+)	159	WP_014295382.1	hypothetical protein	-
H7786_RS01215 (H7786_01225)	-	221804..222130 (+)	327	WP_014295381.1	hypothetical protein	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=416518 H7786_RS01180 WP_002986100.1 216653..217393(+) (comE/blpR) [Streptococcus pyogenes strain TSPY270]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=416518 H7786_RS01180 WP_002986100.1 216653..217393(+) (comE/blpR) [Streptococcus pyogenes strain TSPY270]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCTGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37