Detailed information NTG0415850

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T12_RS08620
• Genome accession: NZ_CP047779
• Coordinates: 1716588..1717631 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1559
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1711588..1722631

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T12_RS08590 (E3T12_08590)	-	1712009..1713265 (-)	1257	WP_001793983.1	aminopeptidase	-
E3T12_RS08595 (E3T12_08595)	-	1713268..1713468 (-)	201	WP_000180460.1	DUF1128 family protein	-
E3T12_RS08600 (E3T12_08600)	-	1713615..1714079 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3T12_RS08605 (E3T12_08605)	-	1714086..1714361 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3T12_RS08610 (E3T12_08610)	-	1714639..1715856 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3T12_RS08615 (E3T12_08615)	vraR	1715969..1716598 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3T12_RS08620 (E3T12_08620)	vraS	1716588..1717631 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T12_RS08625 (E3T12_08625)	liaF	1717628..1718329 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T12_RS08630 (E3T12_08630)	-	1718344..1718730 (-)	387	WP_001110178.1	hypothetical protein	-
E3T12_RS08635 (E3T12_08635)	map	1718947..1719705 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T12_RS08640 (E3T12_08640)	-	1720405..1721391 (+)	987	WP_001014423.1	FUSC family protein	-
E3T12_RS08645 (E3T12_08645)	-	1721580..1721993 (-)	414	WP_001643743.1	hypothetical protein	-
E3T12_RS08650 (E3T12_08650)	-	1722022..1722132 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=415850 E3T12_RS08620 WP_001017131.1 1716588..1717631(-) (vraS) [Staphylococcus aureus strain UP_1559]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=415850 E3T12_RS08620 WP_001017131.1 1716588..1717631(-) (vraS) [Staphylococcus aureus strain UP_1559]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1