Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HZS88_RS17905 Genome accession   NZ_CP058709
Coordinates   3582775..3583434 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain S163-2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3577775..3588434
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HZS88_RS17880 parE 3577866..3579758 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  HZS88_RS17885 ygiN 3579806..3580120 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  HZS88_RS17890 mdaB 3580151..3580732 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  HZS88_RS17895 ygiZ 3581051..3581383 (+) 333 WP_000917684.1 DUF2645 family protein -
  HZS88_RS17900 qseC 3581429..3582778 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  HZS88_RS17905 ciaR 3582775..3583434 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  HZS88_RS17910 ygiW 3583586..3583978 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  HZS88_RS17915 ygiV 3584031..3584513 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  HZS88_RS17920 mqsR 3584718..3585014 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  HZS88_RS17925 mqsA 3585016..3585411 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  HZS88_RS17930 ygiS 3585544..3587151 (+) 1608 WP_063120833.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=406642 HZS88_RS17905 WP_001221493.1 3582775..3583434(-) (ciaR) [Escherichia coli strain S163-2]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=406642 HZS88_RS17905 WP_001221493.1 3582775..3583434(-) (ciaR) [Escherichia coli strain S163-2]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365