Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GE024_RS05715 Genome accession   NZ_CP046521
Coordinates   1124365..1125039 (-) Length   224 a.a.
NCBI ID   WP_003048303.1    Uniprot ID   A0A2D4DMP2
Organism   Streptococcus canis strain HL_100     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1119365..1130039
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GE024_RS05695 (GE024_05705) - 1120528..1121127 (-) 600 WP_003048308.1 class I SAM-dependent methyltransferase -
  GE024_RS05700 (GE024_05710) coaA 1121395..1122315 (+) 921 WP_093998604.1 type I pantothenate kinase -
  GE024_RS05705 (GE024_05715) rpsT 1122369..1122617 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  GE024_RS05710 (GE024_05720) ciaH 1123062..1124372 (-) 1311 WP_093998603.1 cell wall metabolism sensor histidine kinase WalK Regulator
  GE024_RS05715 (GE024_05725) ciaR 1124365..1125039 (-) 675 WP_003048303.1 response regulator transcription factor Regulator
  GE024_RS05720 (GE024_05730) - 1125242..1127779 (-) 2538 WP_093998602.1 M1 family metallopeptidase -
  GE024_RS05725 (GE024_05735) phoU 1127985..1128638 (-) 654 WP_003048299.1 phosphate signaling complex protein PhoU -
  GE024_RS05730 (GE024_05740) pstB 1128716..1129474 (-) 759 WP_003048297.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25693.73 Da        Isoelectric Point: 4.4740

>NTDB_id=404861 GE024_RS05715 WP_003048303.1 1124365..1125039(-) (ciaR) [Streptococcus canis strain HL_100]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLSFGNVVVDLRRKEVQVDGEPIELLGKEFDLLVY
ILQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTGFVDKLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=404861 GE024_RS05715 WP_003048303.1 1124365..1125039(-) (ciaR) [Streptococcus canis strain HL_100]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGTTTATCGAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
GATGCAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGATCTCATGT
TACCAGAAAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGGGAAAAAGATATTAAAATTCCAGTTTTGATTATGACAGCC
AAAGAAAGCATAGATGATAAGGGACATGGGTTTGAACTAGGAGCAGATGATTATCTAACCAAGCCGTTTTACCTTGAAGA
ATTAAAGATGCGCATCCAGGCCCTGTTAAAACGTACGGGCAAATTCACTGATAAAAATCTAAGTTTTGGTAATGTGGTGG
TGGATTTAAGACGAAAAGAAGTTCAAGTCGATGGGGAACCCATTGAGCTATTAGGAAAAGAGTTCGACTTATTGGTTTAC
ATATTGCAAAACCAAAATGTGATCTTACCCAAGACCCAAATTTTTGATCGCTTATGGGGGTTTGACAGCGACACGACAAT
CTCAGTTGTAGAGGTTTATGTCTCTAAAATTAGAAAAAAATTAAAAGGTACTGGTTTTGTTGATAAACTCCAAACCCTGA
GAAGTGTAGGTTATATTCTAAAAAACAATGAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2D4DMP2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus mutans UA159

83.333

99.107

0.826
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  covR Streptococcus salivarius strain HSISS4

36.726

100

0.371
  micA Streptococcus pneumoniae Cp1015

34.615

100

0.362
  vicR Streptococcus mutans UA159

34.615

100

0.362

Multiple sequence alignment