Detailed information NTG0395867

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GFV05_RS05490
• Genome accession: NZ_CP045648
• Coordinates: 1102417..1103463 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain IRL01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1097417..1108463

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GFV05_RS05465 (GFV05_05480)	isaB	1098558..1099094 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
GFV05_RS05470 (GFV05_05485)	-	1099245..1100231 (-)	987	WP_001830388.1	FUSC family protein	-
GFV05_RS05475 (GFV05_05490)	map	1100405..1101160 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
GFV05_RS05480 (GFV05_05495)	-	1101318..1101704 (+)	387	WP_001830382.1	hypothetical protein	-
GFV05_RS05485 (GFV05_05500)	liaF	1101719..1102420 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
GFV05_RS05490 (GFV05_05505)	vraS	1102417..1103463 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
GFV05_RS05495 (GFV05_05510)	vraR	1103453..1104082 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
GFV05_RS05500 (GFV05_05515)	-	1104139..1105317 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
GFV05_RS05505 (GFV05_05520)	-	1105724..1106008 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
GFV05_RS05510 (GFV05_05525)	-	1106016..1106480 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
GFV05_RS05515 (GFV05_05530)	-	1106621..1106836 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
GFV05_RS05520 (GFV05_05535)	-	1106838..1108079 (+)	1242	WP_100481697.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=395867 GFV05_RS05490 WP_001830374.1 1102417..1103463(+) (vraS) [Staphylococcus epidermidis strain IRL01]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=395867 GFV05_RS05490 WP_001830374.1 1102417..1103463(+) (vraS) [Staphylococcus epidermidis strain IRL01]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92