Detailed information NTG0394403

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GBR75_RS09670
• Genome accession: NZ_CP045468
• Coordinates: 1971507..1972550 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SAW1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1966507..1977550

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GBR75_RS09640 (GBR75_09835)	-	1966928..1968184 (-)	1257	WP_078065149.1	aminopeptidase	-
GBR75_RS09645 (GBR75_09840)	-	1968187..1968387 (-)	201	WP_000180460.1	DUF1128 family protein	-
GBR75_RS09650 (GBR75_09845)	-	1968534..1968998 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GBR75_RS09655 (GBR75_09850)	-	1969005..1969280 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
GBR75_RS09660 (GBR75_09855)	-	1969558..1970775 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
GBR75_RS09665 (GBR75_09860)	vraR	1970888..1971517 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
GBR75_RS09670 (GBR75_09865)	vraS	1971507..1972550 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GBR75_RS09675 (GBR75_09870)	liaF	1972547..1973248 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GBR75_RS09680 (GBR75_09875)	-	1973263..1973649 (-)	387	WP_001110179.1	hypothetical protein	-
GBR75_RS09685 (GBR75_09880)	map	1973866..1974624 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
GBR75_RS09690 (GBR75_09885)	-	1975153..1976139 (+)	987	WP_155560248.1	FUSC family protein	-
GBR75_RS09695 (GBR75_09895)	-	1976572..1976985 (-)	414	WP_025174552.1	hypothetical protein	-
GBR75_RS09700 (GBR75_09900)	-	1977014..1977124 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=394403 GBR75_RS09670 WP_001017131.1 1971507..1972550(-) (vraS) [Staphylococcus aureus strain SAW1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=394403 GBR75_RS09670 WP_001017131.1 1971507..1972550(-) (vraS) [Staphylococcus aureus strain SAW1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1