Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   HMPREF0837_RS05685 Genome accession   NC_014251
Coordinates   1084109..1084846 (+) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae TCH8431/19A     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1079109..1089846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0837_RS05665 (HMPREF0837_11183) - 1079306..1080409 (+) 1104 WP_000225901.1 glycosyltransferase -
  HMPREF0837_RS05670 (HMPREF0837_11184) - 1080411..1081397 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  HMPREF0837_RS05675 (HMPREF0837_11185) - 1081413..1082846 (+) 1434 WP_000565084.1 O-antigen polysaccharide polymerase Wzy family protein -
  HMPREF0837_RS05680 (HMPREF0837_11186) - 1082875..1083909 (+) 1035 WP_000461498.1 hypothetical protein -
  HMPREF0837_RS05685 (HMPREF0837_11187) mecA 1084109..1084846 (+) 738 WP_000782676.1 adaptor protein MecA Regulator
  HMPREF0837_RS05690 (HMPREF0837_11188) - 1084997..1086283 (+) 1287 WP_000216372.1 homoserine dehydrogenase -
  HMPREF0837_RS05695 (HMPREF0837_11189) thrB 1086285..1087154 (+) 870 WP_000692436.1 homoserine kinase -
  HMPREF0837_RS13000 (HMPREF0837_11190) - 1087230..1087466 (+) 237 WP_000693047.1 hypothetical protein -
  HMPREF0837_RS05705 (HMPREF0837_11191) msrB 1087495..1088433 (+) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=37605 HMPREF0837_RS05685 WP_000782676.1 1084109..1084846(+) (mecA) [Streptococcus pneumoniae TCH8431/19A]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=37605 HMPREF0837_RS05685 WP_000782676.1 1084109..1084846(+) (mecA) [Streptococcus pneumoniae TCH8431/19A]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment