Detailed information NTG0358841

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: E8M06_RS02720
• Genome accession: NZ_CP039462
• Coordinates: 538219..540447 (-)
• Length: 742 a.a.
• NCBI ID: WP_015646546.1
• Uniprot ID: A0A0M9FFN0
• Organism: Streptococcus suis strain WUSS351
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 533219..545447

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E8M06_RS02700 (E8M06_02700)	-	533653..534096 (+)	444	WP_015646543.1	GNAT family N-acetyltransferase	-
E8M06_RS02705 (E8M06_02705)	ileS	534107..536896 (+)	2790	WP_136581691.1	isoleucine--tRNA ligase	-
E8M06_RS02710 (E8M06_02710)	-	537209..537517 (-)	309	WP_002938710.1	DUF1827 family protein	-
E8M06_RS02715 (E8M06_02715)	-	537572..538033 (-)	462	WP_002938708.1	NUDIX hydrolase	-
E8M06_RS02720 (E8M06_02720)	clpE	538219..540447 (-)	2229	WP_015646546.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
E8M06_RS02725 (E8M06_02725)	-	540671..540901 (+)	231	WP_002938704.1	DUF1797 family protein	-
E8M06_RS02730 (E8M06_02730)	-	541027..541716 (+)	690	WP_002938702.1	amino acid ABC transporter permease	-
E8M06_RS02735 (E8M06_02735)	-	541709..542443 (+)	735	WP_002943067.1	amino acid ABC transporter ATP-binding protein	-
E8M06_RS02740 (E8M06_02740)	-	542677..543525 (+)	849	WP_015646548.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 82596.95 Da
• Isoelectric Point: 5.2782

>NTDB_id=358841 E8M06_RS02720 WP_015646546.1 538219..540447(-) (clpE) [Streptococcus suis strain WUSS351]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPNNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDAENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYDPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide

• Length: 2229 bp

>NTDB_id=358841 E8M06_RS02720 WP_015646546.1 538219..540447(-) (clpE) [Streptococcus suis strain WUSS351]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTAATAATGCCATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTTTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCCCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAACCCTGTTCTTATCGGTGAGCCTGGTGTA
GGTAAAACAGCGGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAGAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACCATTCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCGGTACTGTCCAACCGCTACATTCAAGACCGTTTCCTACCAGACAAAGCTATTGACCTTCTAGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAAGAAATTGACCAACGCCTGATTGATGCCGAAAATCGTAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCGGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAGGAAGATATTCCACTCATTACTGAGAAAGAAATTGAGGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAACCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCAATTGGATCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAGCAATTAGCTATCGAACTCTTCGGTTCGGCGGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTCGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACTGAAAAAGTCCGTCGTAATCCTTATTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGACGATGGGCGTTTGACAGATGGACAAGGTCGGACAGT
CAGCTTCAAAGATACCATCATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGC
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACGATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGACGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (476-639)

• AAA lid domain (AAA_lid_9) (291-389)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (647-721)

• ATPase family associated with various cellular activities (AAA) (AAA) (153-272)

3D structure

• AlphaFold DB: A0A0M9FFN0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus pneumoniae Rx1	82.361	100	0.837
clpE	Streptococcus pneumoniae D39	82.361	100	0.837
clpE	Streptococcus pneumoniae R6	82.361	100	0.837
clpE	Streptococcus pneumoniae TIGR4	82.361	100	0.837
clpE	Streptococcus mutans UA159	82.377	100	0.832
clpC	Lactococcus lactis subsp. cremoris KW2	77.655	97.709	0.759
clpC	Bacillus subtilis subsp. subtilis str. 168	52.462	87.601	0.46
clpC	Streptococcus mutans UA159	48.558	84.097	0.408
clpC	Streptococcus thermophilus LMD-9	48.248	84.636	0.408
clpC	Streptococcus thermophilus LMG 18311	47.93	84.636	0.406
clpC	Streptococcus pneumoniae TIGR4	47.84	84.232	0.403
clpC	Streptococcus pneumoniae Rx1	47.84	84.232	0.403
clpC	Streptococcus pneumoniae D39	47.84	84.232	0.403
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.815	84.636	0.396