Detailed information NTG0352684

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ES298_RS02520
• Genome accession: NZ_CP038253
• Coordinates: 498989..499726 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain TVO_1901929
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 493989..504726

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES298_RS02485 (ES298_02620)	-	494919..495158 (-)	240	WP_001810235.1	hypothetical protein	-
ES298_RS02490 (ES298_02625)	-	495320..495607 (-)	288	WP_000777760.1	hypothetical protein	-
ES298_RS02495 (ES298_02630)	-	495617..496027 (-)	411	WP_001278299.1	HIT family protein	-
ES298_RS02500 (ES298_02635)	pptA	496095..496826 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
ES298_RS02505 (ES298_02640)	-	496823..497872 (+)	1050	WP_000653767.1	ABC transporter permease	-
ES298_RS02510 (ES298_02645)	-	498040..498369 (-)	330	WP_000132572.1	hypothetical protein	-
ES298_RS02515 (ES298_02650)	-	498646..498984 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
ES298_RS02520 (ES298_02655)	comE/blpR	498989..499726 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ES298_RS02525 (ES298_02660)	-	499740..501080 (+)	1341	WP_001017638.1	sensor histidine kinase	-
ES298_RS02530 (ES298_02665)	blpC	501122..501277 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
ES298_RS02535 (ES298_02670)	-	501334..502695 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
ES298_RS02540 (ES298_02675)	comA/nlmT	502706..504382 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=352684 ES298_RS02520 WP_001219120.1 498989..499726(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901929]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=352684 ES298_RS02520 WP_001219120.1 498989..499726(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901929]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363