Detailed information NTG0341085

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT70_RS00330
• Genome accession: NZ_CP035429
• Coordinates: 53234..54145 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emmNA
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48234..59145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT70_RS00310 (ETT70_00310)	purE	48529..49020 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT70_RS00315 (ETT70_00315)	purK	49007..50080 (+)	1074	WP_168640767.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT70_RS00320 (ETT70_00320)	-	50101..51441 (+)	1341	WP_023611329.1	hypothetical protein	-
ETT70_RS00325 (ETT70_00325)	purB	51810..53102 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
ETT70_RS00330 (ETT70_00330)	comR	53234..54145 (+)	912	WP_014635220.1	XRE family transcriptional regulator	Regulator
ETT70_RS09285	comS	54236..54334 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT70_RS00335 (ETT70_00335)	ruvB	54365..55363 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ETT70_RS00340 (ETT70_00340)	-	55501..55938 (+)	438	WP_136112731.1	low molecular weight protein-tyrosine-phosphatase	-
ETT70_RS00345 (ETT70_00345)	-	55961..56362 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT70_RS00350 (ETT70_00350)	-	56359..58134 (+)	1776	WP_032460527.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=341085 ETT70_RS00330 WP_014635220.1 53234..54145(+) (comR) [Streptococcus pyogenes strain emmNA]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=341085 ETT70_RS00330 WP_014635220.1 53234..54145(+) (comR) [Streptococcus pyogenes strain emmNA]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366