Detailed information NTG0337897

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EQH26_RS02710
• Genome accession: NZ_CP035254
• Coordinates: 521788..522525 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain TVO_1901932
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 516788..527525

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH26_RS02675	-	517718..517957 (-)	240	WP_001813906.1	hypothetical protein	-
EQH26_RS02680 (EQH26_02855)	-	518119..518406 (-)	288	WP_000777760.1	hypothetical protein	-
EQH26_RS02685 (EQH26_02860)	-	518416..518826 (-)	411	WP_001278301.1	HIT family protein	-
EQH26_RS02690 (EQH26_02865)	pptA	518894..519625 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
EQH26_RS02695 (EQH26_02870)	-	519622..520671 (+)	1050	WP_000653767.1	ABC transporter permease	-
EQH26_RS02700 (EQH26_02875)	-	520839..521168 (-)	330	WP_238126626.1	helicase BlpT	-
EQH26_RS02705 (EQH26_02880)	-	521445..521783 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
EQH26_RS02710 (EQH26_02885)	comE/blpR	521788..522525 (+)	738	WP_001219122.1	LytTR family DNA-binding domain-containing protein	Regulator
EQH26_RS02715 (EQH26_02890)	-	522538..523878 (+)	1341	WP_000275285.1	sensor histidine kinase	-
EQH26_RS02720 (EQH26_02895)	blpC	523922..524077 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
EQH26_RS02725 (EQH26_02900)	-	524276..525622 (+)	1347	WP_001821937.1	IS1380-like element ISSpn5 family transposase	-
EQH26_RS02730 (EQH26_02905)	-	525842..527203 (-)	1362	WP_001069093.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=337897 EQH26_RS02710 WP_001219122.1 521788..522525(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901932]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=337897 EQH26_RS02710 WP_001219122.1 521788..522525(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901932]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38