Detailed information NTG0310190

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ES276_RS01670
• Genome accession: NZ_CP038252
• Coordinates: 307421..308320 (+)
• Length: 299 a.a.
• NCBI ID: WP_000904858.1
• Uniprot ID: A0A0H2URY1
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 302421..313320

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS01640 (ES276_01735)	-	302591..302885 (+)	295	Protein_314	hypothetical protein	-
ES276_RS01645 (ES276_01740)	-	303041..304255 (+)	1215	WP_000666469.1	pyridoxal phosphate-dependent aminotransferase	-
ES276_RS01650 (ES276_01745)	rpmH	304400..304534 (+)	135	WP_000831905.1	50S ribosomal protein L34	-
ES276_RS01655 (ES276_01750)	-	304740..305711 (+)	972	Protein_317	DUF1542 domain-containing protein	-
ES276_RS01660 (ES276_01760)	-	306016..306789 (+)	774	WP_000575607.1	TatD family hydrolase	-
ES276_RS01665 (ES276_01765)	rnmV	306789..307349 (+)	561	WP_000660004.1	ribonuclease M5	-
ES276_RS01670 (ES276_01770)	comR	307421..308320 (+)	900	WP_000904858.1	helix-turn-helix transcriptional regulator	Regulator
ES276_RS01675 (ES276_01775)	-	308589..310619 (+)	2031	WP_000825267.1	bacteriocin-associated integral membrane family protein	-
ES276_RS01680 (ES276_01780)	-	310621..311262 (+)	642	WP_000565531.1	ABC transporter ATP-binding protein	-
ES276_RS01685 (ES276_01785)	-	311255..311563 (+)	309	WP_000333257.1	hypothetical protein	-
ES276_RS01690 (ES276_01790)	rsmA	311694..312566 (+)	873	WP_001216856.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35409.11 Da
• Isoelectric Point: 4.7119

>NTDB_id=310190 ES276_RS01670 WP_000904858.1 307421..308320(+) (comR) [Streptococcus pneumoniae strain TVO_1901936]
MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPSLPKLDYIARRLGVPVYSLMPDFSALPSAYLELKYQI
LREPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLL
IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTQIENYFIIRDTLISGMCCLEKVGVTDCFNDYLSCLQEIMDKTQDY
QKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEWQEDVKKYL

Nucleotide

• Length: 900 bp

>NTDB_id=310190 ES276_RS01670 WP_000904858.1 307421..308320(+) (comR) [Streptococcus pneumoniae strain TVO_1901936]
ATGTTAATTGGTCAAAAAATTAAAGAGATTCGGATAGAAAAAGGAATTAGTCGTCCAGATTTTTGTGGAGATGAGCAAGA
ACTGACAGTTCGTCAACTGTCGCGAATTGAAAGTGGAGCTTCGCAACCGAGTTTGCCCAAGTTAGACTATATTGCTCGCC
GGCTAGGAGTTCCAGTTTATAGCCTTATGCCGGATTTTTCAGCTCTTCCTTCTGCTTATTTAGAATTGAAATACCAGATT
TTACGTGAACCAATCTATGGTAAAGAAGAGGAGTACGATAAGAAGGAAGCGTGTTTGGAAGAGATTTATAAAACATACTT
TGATAATCTTCCTAAAGAAGAACAATTAGCATGTGAAGTATTGCAGGCGTGTTTGGATACTTCTAGAACTAGAAGGCCTG
AATATGCAGAGTTAATACTTGAGGAACATATGCCTCAGATTATAGAAAAAGAAGCTTATTCAATAAATGATATGTTGTTG
ATTCGTTTGTTTTTTTATCAAATGCTCATTAGAAAAGATCTTGCCAAATTTATAAATCAAATCGAAAAGCTAATGCTCTT
TCTTTTGGAACAGAAGAAGGTAACTCAAATAGAGAATTACTTTATAATTAGAGATACTCTTATTTCAGGAATGTGTTGTC
TTGAAAAGGTAGGAGTAACTGATTGTTTTAATGATTATCTATCGTGTTTACAAGAAATTATGGATAAAACTCAAGATTAT
CAAAAGAAACCTCTTGTATTTATGTTTTTGTGGAAGCAAGCATTAAGAGAAGAAAGAGATTTTAGTTTAGCTGAATCATT
TTATCAGTCTTCTAAAACATTTGCGCAGCTAATTGGAGATGAATTTCTAGTAAAGAAATTGACAGAGGAATGGCAAGAGG
ATGTCAAAAAATATTTATAA

Domains

Predicted by InterProScan.

• ComR tetratricopeptide (ComR_TPR) (70-291)

3D structure

• AlphaFold DB: A0A0H2URY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	37.755	98.328	0.371
comR	Streptococcus suis P1/7	37.457	97.324	0.365
comR	Streptococcus suis 05ZYH33	37.457	97.324	0.365
comR	Streptococcus pyogenes MGAS8232	36.242	99.666	0.361