Detailed information NTG0303347

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT46_RS02450
• Genome accession: NZ_CP035453
• Coordinates: 436393..438546 (-)
• Length: 717 a.a.
• NCBI ID: WP_136265289.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm100
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 431393..443546

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT46_RS02430 (ETT46_02430)	comE/blpR	432584..433333 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
ETT46_RS02435 (ETT46_02435)	-	433334..434668 (+)	1335	WP_136115031.1	sensor histidine kinase	-
ETT46_RS02440 (ETT46_02440)	-	434816..434941 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT46_RS02445 (ETT46_02445)	-	435018..436382 (-)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
ETT46_RS02450 (ETT46_02450)	comA/nlmT	436393..438546 (-)	2154	WP_136265289.1	peptide cleavage/export ABC transporter	Regulator
ETT46_RS02460 (ETT46_02460)	-	438999..439684 (+)	686	Protein_425	transposase	-
ETT46_RS02465 (ETT46_02465)	-	439872..440117 (+)	246	WP_002994504.1	Blp family class II bacteriocin	-
ETT46_RS02470 (ETT46_02470)	-	440132..440314 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT46_RS02475 (ETT46_02475)	-	440505..441190 (-)	686	Protein_428	transposase	-
ETT46_RS02480 (ETT46_02480)	-	441509..441736 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
ETT46_RS02485 (ETT46_02485)	-	441749..441949 (+)	201	WP_002985729.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT46_RS09635 (ETT46_02495)	-	442310..442438 (+)	129	WP_002985724.1	hypothetical protein	-
ETT46_RS02505 (ETT46_02505)	-	442962..443363 (+)	402	WP_023605036.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80631.51 Da
• Isoelectric Point: 6.8705

>NTDB_id=303347 ETT46_RS02450 WP_136265289.1 436393..438546(-) (comA/nlmT) [Streptococcus pyogenes strain emm100]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLDIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQSFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=303347 ETT46_RS02450 WP_136265289.1 436393..438546(-) (comA/nlmT) [Streptococcus pyogenes strain emm100]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGACATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAAGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.727	99.721	0.725
comA	Streptococcus mitis NCTC 12261	67.37	99.163	0.668
comA	Streptococcus mitis SK321	66.948	99.163	0.664
comA	Streptococcus pneumoniae Rx1	66.948	99.163	0.664
comA	Streptococcus pneumoniae D39	66.948	99.163	0.664
comA	Streptococcus pneumoniae R6	66.948	99.163	0.664
comA	Streptococcus pneumoniae TIGR4	66.667	99.163	0.661
comA	Streptococcus gordonii str. Challis substr. CH1	65.874	99.721	0.657