Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ETT47_RS06340 Genome accession   NZ_CP035452
Coordinates   1269059..1269700 (-) Length   213 a.a.
NCBI ID   WP_032465159.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm123     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1264059..1274700
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT47_RS06315 (ETT47_06305) comFA/cflA 1264146..1265471 (-) 1326 WP_136018894.1 DEAD/DEAH box helicase Machinery gene
  ETT47_RS06320 (ETT47_06310) - 1265526..1266158 (+) 633 WP_009880468.1 YigZ family protein -
  ETT47_RS06325 (ETT47_06315) cysK 1266286..1267227 (+) 942 WP_010922535.1 cysteine synthase A -
  ETT47_RS06330 (ETT47_06320) - 1267245..1267622 (-) 378 WP_109991563.1 S1 RNA-binding domain-containing protein -
  ETT47_RS06335 (ETT47_06325) - 1267622..1269022 (-) 1401 WP_136099283.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ETT47_RS06340 (ETT47_06330) vraR 1269059..1269700 (-) 642 WP_032465159.1 response regulator transcription factor Regulator
  ETT47_RS06345 (ETT47_06335) - 1269693..1270697 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ETT47_RS06350 (ETT47_06340) liaF 1270694..1271386 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ETT47_RS06355 (ETT47_06345) pknB 1271509..1273407 (-) 1899 WP_109991562.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ETT47_RS06360 (ETT47_06350) - 1273404..1274144 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23723.38 Da        Isoelectric Point: 5.0119

>NTDB_id=303286 ETT47_RS06340 WP_032465159.1 1269059..1269700(-) (vraR) [Streptococcus pyogenes strain emm123]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFQHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=303286 ETT47_RS06340 WP_032465159.1 1269059..1269700(-) (vraR) [Streptococcus pyogenes strain emm123]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCAACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

53.398

96.714

0.516
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment