Detailed information NTG0302558

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT54_RS00265
• Genome accession: NZ_CP035445
• Coordinates: 47241..48152 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm92
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42241..53152

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT54_RS00245 (ETT54_00245)	purE	42525..43016 (+)	492	WP_136098267.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT54_RS00250 (ETT54_00250)	purK	43003..44076 (+)	1074	WP_029714261.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT54_RS00255 (ETT54_00255)	-	44103..45800 (+)	1698	WP_136098268.1	AIPR family protein	-
ETT54_RS00260 (ETT54_00260)	purB	45818..47110 (+)	1293	WP_129321630.1	adenylosuccinate lyase	-
ETT54_RS00265 (ETT54_00265)	comR	47241..48152 (+)	912	WP_020904818.1	XRE family transcriptional regulator	Regulator
ETT54_RS08880	comS	48243..48341 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT54_RS00270 (ETT54_00270)	ruvB	48372..49370 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	Machinery gene
ETT54_RS00275 (ETT54_00275)	-	49508..49945 (+)	438	WP_111689441.1	low molecular weight protein-tyrosine-phosphatase	-
ETT54_RS00280 (ETT54_00280)	-	49968..50369 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT54_RS00285 (ETT54_00285)	-	50366..52141 (+)	1776	WP_053308140.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=302558 ETT54_RS00265 WP_020904818.1 47241..48152(+) (comR) [Streptococcus pyogenes strain emm92]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=302558 ETT54_RS00265 WP_020904818.1 47241..48152(+) (comR) [Streptococcus pyogenes strain emm92]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterProScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366