Detailed information NTG0295396

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DMC40_RS00330
• Genome accession: NZ_CP029694
• Coordinates: 53472..54383 (+)
• Length: 303 a.a.
• NCBI ID: WP_011054099.1
• Uniprot ID: A0A5S4TJF2
• Organism: Streptococcus pyogenes strain ABC020055975
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48472..59383

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DMC40_RS00310 (DMC40_00310)	purE	48769..49260 (+)	492	WP_030127619.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DMC40_RS00315 (DMC40_00315)	purK	49247..50320 (+)	1074	WP_032461293.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DMC40_RS00320 (DMC40_00320)	-	50341..51681 (+)	1341	WP_002986685.1	hypothetical protein	-
DMC40_RS00325 (DMC40_00325)	purB	52050..53342 (+)	1293	WP_011054098.1	adenylosuccinate lyase	-
DMC40_RS00330 (DMC40_00330)	comR	53472..54383 (+)	912	WP_011054099.1	XRE family transcriptional regulator	Regulator
DMC40_RS09905	comS	54474..54572 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
DMC40_RS00335 (DMC40_00335)	ruvB	54603..55601 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
DMC40_RS00340 (DMC40_00340)	-	55739..56176 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
DMC40_RS00345 (DMC40_00345)	-	56199..56600 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
DMC40_RS00350 (DMC40_00350)	-	56597..58372 (+)	1776	WP_011054101.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35896.55 Da
• Isoelectric Point: 4.9324

>NTDB_id=295396 DMC40_RS00330 WP_011054099.1 53472..54383(+) (comR) [Streptococcus pyogenes strain ABC020055975]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGHLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=295396 DMC40_RS00330 WP_011054099.1 53472..54383(+) (comR) [Streptococcus pyogenes strain ABC020055975]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCATCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

3D structure

• AlphaFold DB: A0A5S4TJF2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	100	100	1
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366