Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPN23F_RS03705 Genome accession   NC_011900
Coordinates   709854..710528 (+) Length   224 a.a.
NCBI ID   WP_000590619.1    Uniprot ID   -
Organism   Streptococcus pneumoniae ATCC 700669     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 704854..715528
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN23F_RS03690 (SPN23F07240) - 705213..705653 (+) 441 WP_000612881.1 ASCH domain-containing protein -
  SPN23F_RS03695 (SPN23F07250) - 705776..708322 (+) 2547 WP_001149115.1 M1 family metallopeptidase -
  SPN23F_RS03700 (SPN23F07260) - 708380..709636 (-) 1257 WP_000436228.1 ISL3-like element IS1167A family transposase -
  SPN23F_RS03705 (SPN23F07270) ciaR 709854..710528 (+) 675 WP_000590619.1 two-component system response regulator CiaR Regulator
  SPN23F_RS03710 (SPN23F07280) ciaH 710518..711852 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  SPN23F_RS03715 (SPN23F07290) - 711886..712173 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  SPN23F_RS03720 (SPN23F07300) - 712313..713242 (+) 930 WP_000411854.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=29459 SPN23F_RS03705 WP_000590619.1 709854..710528(+) (ciaR) [Streptococcus pneumoniae ATCC 700669]
MIKILLIEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=29459 SPN23F_RS03705 WP_000590619.1 709854..710528(+) (ciaR) [Streptococcus pneumoniae ATCC 700669]
ATGATAAAAATCTTATTGATTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366

Multiple sequence alignment