Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SSA_RS04750 Genome accession   NC_009009
Coordinates   968646..970037 (+) Length   463 a.a.
NCBI ID   WP_002904314.1    Uniprot ID   A3CMH5
Organism   Streptococcus sanguinis SK36     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 963646..975037
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS04725 - 965746..966030 (+) 285 WP_002900560.1 helix-turn-helix domain-containing protein -
  SSA_RS04730 - 966086..966412 (+) 327 WP_002900559.1 DMT family transporter -
  SSA_RS04735 (SSA_0957) - 966416..967231 (+) 816 WP_011836824.1 SDR family NAD(P)-dependent oxidoreductase -
  SSA_RS04740 (SSA_0958) - 967413..967877 (+) 465 WP_011836825.1 hypothetical protein -
  SSA_RS04745 (SSA_0959) ciaR 967982..968656 (+) 675 WP_002897753.1 response regulator transcription factor Regulator
  SSA_RS04750 (SSA_0960) ciaH 968646..970037 (+) 1392 WP_002904314.1 sensor histidine kinase Regulator
  SSA_RS04755 (SSA_0961) - 970053..970991 (+) 939 WP_011836826.1 ketopantoate reductase family protein -
  SSA_RS04760 (SSA_0962) - 971105..971491 (+) 387 WP_002895748.1 VOC family protein -
  SSA_RS04765 (SSA_0963) - 971553..972950 (+) 1398 WP_011836827.1 polysaccharide deacetylase family protein -
  SSA_RS04770 (SSA_0964) - 973044..974135 (-) 1092 WP_033179140.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 463 a.a.        Molecular weight: 52603.01 Da        Isoelectric Point: 8.4934

>NTDB_id=26289 SSA_RS04750 WP_002904314.1 968646..970037(+) (ciaH) [Streptococcus sanguinis SK36]
MLNKIKKTFYADDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTSVDENLKNLSNDPSSVADLAYRTTGQQSDPSNKVN
SKSPKSSKEPDGDSDEEPKPNNLTTPNVSSNTFALLLDDDYKNISTSKSDGFLDFNSLEFNKSYLNQIKEIVIGNSFGQT
ESYRAYLFDIDPKNEYPDIKYAVVMTSISQLEQTSSKHEQLIAMVMVSFWGISLIASIYLARMSVKPLLESIQKQKAFVE
NASHELRTPLAVLQSRLETLFRKPEATIMQSSENIASSLDEVRNMRLLTTNLLNLARRDDGIKPQYGEVEPEFFDTTFAN
YCIIARENKKAFHSENMIKHPIVTDQIFLKQLMTILFDNAIKYTDDDGVISVMATSTDRYLIFRVADNGPGISDEDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAKQIVDAFKGSIYVKDNKPKGTVFEVKLLLKETKKRSVK

Nucleotide


Download         Length: 1392 bp        

>NTDB_id=26289 SSA_RS04750 WP_002904314.1 968646..970037(+) (ciaH) [Streptococcus sanguinis SK36]
ATGCTGAATAAAATCAAGAAGACCTTTTATGCGGATGATTTCTCTTATTTCATTCGCTATTTTGGGTTGTTTACATTAAT
CTTCTCAGCCATGACCTTGATTATTATTCAGGTTATGCGCTCCAGCCTTTATACGTCAGTTGATGAAAATCTGAAAAACC
TGAGTAATGATCCTAGTTCAGTAGCTGATTTGGCCTATCGGACGACAGGTCAGCAGTCTGATCCGAGCAATAAGGTCAAT
TCTAAAAGTCCTAAAAGCAGTAAAGAGCCAGATGGCGATTCAGATGAAGAGCCTAAGCCTAACAATCTAACTACGCCAAA
TGTTAGCTCTAATACCTTTGCCTTGCTTTTGGATGATGATTATAAAAATATTTCCACCAGCAAGAGCGATGGTTTTCTGG
ACTTTAATTCATTAGAGTTTAACAAGTCCTATCTGAATCAAATCAAGGAAATTGTGATTGGCAACAGCTTTGGTCAGACA
GAAAGTTATCGGGCTTATCTCTTTGATATTGATCCTAAAAATGAGTACCCTGATATCAAGTACGCTGTGGTCATGACTAG
TATCAGCCAGCTAGAGCAGACCAGCAGCAAGCATGAGCAGTTGATTGCCATGGTCATGGTCAGCTTTTGGGGAATTTCCC
TGATTGCCAGTATTTACCTTGCTCGGATGAGTGTCAAGCCTCTGCTGGAAAGTATCCAGAAGCAGAAGGCTTTCGTGGAA
AATGCCAGTCACGAGCTACGGACTCCTCTGGCAGTATTGCAGAGCCGCTTAGAGACGCTCTTTCGTAAGCCTGAAGCTAC
AATCATGCAGAGCAGTGAAAATATTGCTTCTAGCTTGGATGAAGTACGCAATATGCGCTTGCTGACGACCAATCTGCTCA
ATCTGGCTCGTCGCGATGATGGCATCAAACCTCAATATGGTGAAGTCGAACCAGAATTTTTTGATACGACCTTTGCTAAT
TACTGTATTATCGCAAGGGAGAATAAAAAAGCCTTTCATTCAGAAAATATGATTAAGCACCCTATTGTGACCGATCAAAT
TTTTCTCAAACAACTGATGACCATTCTATTTGACAATGCTATCAAGTATACAGATGATGATGGCGTAATCAGTGTCATGG
CTACTTCGACAGATCGCTACCTTATTTTCCGAGTGGCGGACAATGGTCCTGGTATCAGCGATGAAGATAAGAAGAAGATT
TTTGATCGCTTTTATCGGGTGGACAAGGCTCGGACCCGTCAGAAAGGTGGCTTTGGTCTGGGACTTTCTTTGGCCAAGCA
GATTGTCGATGCTTTCAAAGGCTCTATTTATGTCAAGGACAACAAACCAAAAGGTACGGTCTTTGAAGTTAAACTGCTCC
TGAAAGAAACGAAAAAGCGTTCTGTTAAATAG

Domains

Predicted by InterProScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(236-301)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(344-454)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A3CMH5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae D39

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae R6

60.738

99.568

0.605
  ciaH Streptococcus pneumoniae TIGR4

60.738

99.568

0.605
  ciaH Streptococcus mutans UA159

53.289

98.488

0.525

Multiple sequence alignment