Detailed information NTG0025822

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS9429_RS00325
• Genome accession: NC_008021
• Coordinates: 53074..53985 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS9429
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48074..58985

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS9429_RS00305 (MGAS9429_Spy0030)	purE	48367..48858 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS9429_RS00310 (MGAS9429_Spy0031)	purK	48845..49918 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS9429_RS00315 (MGAS9429_Spy0032)	-	49939..51279 (+)	1341	WP_002987721.1	hypothetical protein	-
MGAS9429_RS00320 (MGAS9429_Spy0034)	purB	51648..52940 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
MGAS9429_RS00325 (MGAS9429_Spy0035)	comR	53074..53985 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS9429_RS10035	comS	54069..54164 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS9429_RS00330 (MGAS9429_Spy0036)	ruvB	54211..55209 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS9429_RS00335 (MGAS9429_Spy0037)	-	55347..55784 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS9429_RS00340 (MGAS9429_Spy0038)	-	55808..56209 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
MGAS9429_RS00345 (MGAS9429_Spy0039)	-	56206..57981 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=25822 MGAS9429_RS00325 WP_002986681.1 53074..53985(+) (comR) [Streptococcus pyogenes MGAS9429]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=25822 MGAS9429_RS00325 WP_002986681.1 53074..53985(+) (comR) [Streptococcus pyogenes MGAS9429]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462