Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   DMC40_RS04380 Genome accession   NZ_CP029694
Coordinates   786972..787634 (+) Length   220 a.a.
NCBI ID   WP_002995626.1    Uniprot ID   A0A0H2UV22
Organism   Streptococcus pyogenes strain ABC020055975     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 781972..792634
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DMC40_RS04360 (DMC40_04360) - 782846..784846 (+) 2001 WP_011054663.1 potassium transporter Kup -
  DMC40_RS04365 (DMC40_04365) - 784870..785148 (-) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  DMC40_RS04370 (DMC40_04370) - 785138..785914 (-) 777 WP_002994360.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  DMC40_RS04375 (DMC40_04375) - 786032..786772 (+) 741 WP_011054661.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  DMC40_RS04380 (DMC40_04380) comEA/celA/cilE 786972..787634 (+) 663 WP_002995626.1 ComEA family DNA-binding protein Machinery gene
  DMC40_RS04385 (DMC40_04385) comEC/celB 787615..789858 (+) 2244 WP_011106716.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  DMC40_RS04390 (DMC40_04390) holA 789929..790969 (+) 1041 WP_011054659.1 DNA polymerase III subunit delta -
  DMC40_RS04395 (DMC40_04395) sodA 791066..791671 (+) 606 WP_011054658.1 superoxide dismutase SodA -
  DMC40_RS04400 (DMC40_04400) - 791838..792065 (+) 228 WP_011054657.1 hypothetical protein -
  DMC40_RS04405 (DMC40_04405) - 792050..792298 (+) 249 WP_011054656.1 hypothetical protein -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 24623.45 Da        Isoelectric Point: 6.7451

>NTDB_id=257091 DMC40_RS04380 WP_002995626.1 786972..787634(+) (comEA/celA/cilE) [Streptococcus pyogenes strain ABC020055975]
MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLK
GAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD

Nucleotide


Download         Length: 663 bp        

>NTDB_id=257091 DMC40_RS04380 WP_002995626.1 786972..787634(+) (comEA/celA/cilE) [Streptococcus pyogenes strain ABC020055975]
ATGTTAGACGAATTATTAATTAAAGGAAAATCGTTTTTGAGAGAGCGGTATTTTTTGCCATACCTAATTAGTCTTTTATT
AGGACTTTTTCTAATACTAAGCTTCAGTTTTTTGTTCTGGGGAAATAGGCAGAGCAAGGCAGCCGTTCCTGCTTTGAGAG
AAATATCGCCTGTGAAACAGCAGGTTAGTGAAGAAAAAAAGGAAATTCAAGAAGATAATAGTATTTTAGTGGATTTAAAA
GGCGCCGTACAAAAAGAGGGAGTTTATAAGCTAACTGCTAGCAGTCGTGTGCGAGATGTCATTGAACTAGCTGGAGGCCT
AACTTCAGAAGCTGATAAACATGCTATTAATTTTGCAGAAAAACTAACTGATGAGCAAGTTGTTTATGTACCTAAACAAG
GAGAAGAGATTTCTGTGCTACCAAGGTCATTAGTTTCTGGTAAAAAAGAAACTGCCAGCAAGGATCAGTCAAAGGTTCAT
ATTAATAAGGCCAGCTTAGAAGAACTACAACATATCCCAGGTATTGGTGCTAAAAGAGCTCAGGATATTATTGATATGAG
AGATAAGTTAGGTGGTTTTAAAGCGTTAGAAGATCTCCGTCAGGTTTCGGGGATTGGCGAAAAAACGCTCGAGAAATTAA
AAGATGACATTTTCTTGGACTAA

Domains

Predicted by InterProScan.

SLBB domain (SLBB)

(77-130)

Helix-hairpin-helix motif (HHH_3)

(156-217)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UV22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

42.995

94.091

0.405

Multiple sequence alignment