Detailed information NTG0239378

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: CGZ53_RS03035
• Genome accession: NZ_CP022435
• Coordinates: 555028..555750 (+)
• Length: 240 a.a.
• NCBI ID: WP_012658092.1
• Uniprot ID: B9DRI3
• Organism: Streptococcus uberis strain NZ01
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 550028..560750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CGZ53_RS03005 (CGZ53_02995)	-	550118..550615 (+)	498	WP_012658085.1	YkgJ family cysteine cluster protein	-
CGZ53_RS03010 (CGZ53_03000)	-	550653..551597 (-)	945	WP_046391184.1	peptidoglycan recognition family protein	-
CGZ53_RS03015 (CGZ53_03005)	-	551690..552325 (+)	636	WP_046391185.1	NAD-dependent epimerase/dehydratase family protein	-
CGZ53_RS03020 (CGZ53_03010)	-	552384..553199 (-)	816	WP_037592353.1	TIGR03943 family putative permease subunit	-
CGZ53_RS03025 (CGZ53_03015)	-	553196..554104 (-)	909	WP_046389192.1	permease	-
CGZ53_RS09495	-	554156..554302 (-)	147	WP_012658090.1	SPJ_0845 family protein	-
CGZ53_RS03030 (CGZ53_03020)	-	554494..554877 (+)	384	WP_012658091.1	VOC family protein	-
CGZ53_RS03035 (CGZ53_03025)	vicR	555028..555750 (+)	723	WP_012658092.1	response regulator transcription factor	Regulator
CGZ53_RS03040 (CGZ53_03030)	pnpS	555734..557059 (+)	1326	WP_012658093.1	two-component system histidine kinase PnpS	-
CGZ53_RS03045 (CGZ53_03035)	-	557232..558113 (+)	882	WP_012658094.1	substrate-binding domain-containing protein	-
CGZ53_RS03050 (CGZ53_03040)	pstC	558179..559042 (+)	864	WP_012658095.1	phosphate ABC transporter permease subunit PstC	-
CGZ53_RS03055 (CGZ53_03045)	pstA	559035..559850 (+)	816	WP_012658096.1	phosphate ABC transporter permease PstA	-
CGZ53_RS03060 (CGZ53_03050)	pstB	559852..560604 (+)	753	WP_100911955.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 240 a.a.
• Molecular weight: 28359.83 Da
• Isoelectric Point: 6.3173

>NTDB_id=239378 CGZ53_RS03035 WP_012658092.1 555028..555750(+) (vicR) [Streptococcus uberis strain NZ01]
MKKHILLVDDEEHILRLLDYHLKKEGYETDLAEDGRTALKLAESEHYDFILLDIMLPQLDGIEVCKRIRSKGNKTPIMMV
SAKGEEFDKVLALELGADDYMTKPFSPRELIARLKAILRRTEKTEEEDTTGLPEEYWTINHLVIYPERHEVYKNQKLLNL
TPKEFELLLYLVKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDDPKKPVFIKTIRGYGYKFKELKDETKS

Nucleotide

• Length: 723 bp

>NTDB_id=239378 CGZ53_RS03035 WP_012658092.1 555028..555750(+) (vicR) [Streptococcus uberis strain NZ01]
ATGAAAAAACATATTTTATTAGTCGATGATGAAGAACATATCTTACGTCTATTAGATTATCATTTGAAAAAAGAAGGTTA
TGAGACAGATCTTGCTGAGGATGGTAGGACAGCGCTAAAACTAGCAGAATCTGAACATTATGATTTTATTTTATTAGACA
TTATGTTGCCACAATTAGATGGTATTGAAGTCTGTAAAAGAATCCGTTCCAAGGGAAACAAGACTCCAATTATGATGGTA
TCTGCTAAAGGGGAGGAGTTTGATAAAGTACTAGCACTTGAACTTGGTGCTGATGATTATATGACAAAACCTTTTAGTCC
TAGAGAGTTAATTGCCAGATTAAAGGCTATTTTAAGACGAACTGAAAAAACTGAAGAAGAGGATACTACAGGTTTACCAG
AAGAATATTGGACTATTAATCACTTGGTTATTTATCCTGAAAGGCATGAAGTTTATAAAAATCAAAAGTTACTAAATCTA
ACACCGAAAGAATTTGAACTCTTACTTTATCTAGTCAAACATCCTAATATGACTCTAACAAGAGAACGACTCTTAGAACG
GATATGGGGTTATGATTTTGGACAAGAAACCCGTTTGGTAGATGTCCATATTGGTAAGTTGAGAGAAAAAATTGAGGATG
ATCCTAAAAAACCAGTGTTTATCAAAACGATTCGTGGATATGGTTATAAATTTAAGGAGCTAAAGGATGAAACAAAATCT
TAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-114)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (158-231)

3D structure

• AlphaFold DB: B9DRI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	52.137	97.5	0.508
micA	Streptococcus pneumoniae Cp1015	49.573	97.5	0.483
covR	Lactococcus lactis subsp. lactis strain DGCC12653	42.308	97.5	0.413
covR	Streptococcus salivarius strain HSISS4	40.343	97.083	0.392