Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   C7K40_RS06720 Genome accession   NZ_CP027771
Coordinates   1331288..1331929 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain DMG1800716     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1326288..1336929
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C7K40_RS06695 (C7K40_06690) comFA/cflA 1326373..1327698 (-) 1326 WP_063629559.1 DEAD/DEAH box helicase Machinery gene
  C7K40_RS06700 (C7K40_06695) - 1327754..1328386 (+) 633 WP_009880468.1 YigZ family protein -
  C7K40_RS06705 (C7K40_06700) cysK 1328514..1329455 (+) 942 WP_011888673.1 cysteine synthase A -
  C7K40_RS06710 (C7K40_06705) - 1329474..1329851 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  C7K40_RS06715 (C7K40_06710) - 1329851..1331251 (-) 1401 WP_023612963.1 Cof-type HAD-IIB family hydrolase -
  C7K40_RS06720 (C7K40_06715) vraR 1331288..1331929 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  C7K40_RS06725 (C7K40_06720) - 1331922..1332926 (-) 1005 WP_002991890.1 sensor histidine kinase -
  C7K40_RS06730 (C7K40_06725) liaF 1332923..1333615 (-) 693 WP_023612959.1 cell wall-active antibiotics response protein LiaF -
  C7K40_RS06735 (C7K40_06730) pknB 1333738..1335636 (-) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  C7K40_RS06740 (C7K40_06735) - 1335633..1336373 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=237206 C7K40_RS06720 WP_002983671.1 1331288..1331929(-) (vraR) [Streptococcus pyogenes strain DMG1800716]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=237206 C7K40_RS06720 WP_002983671.1 1331288..1331929(-) (vraR) [Streptococcus pyogenes strain DMG1800716]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTGCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385