Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   MW_RS00205 Genome accession   NC_003923
Coordinates   48017..49366 (-) Length   449 a.a.
NCBI ID   WP_000815641.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus MW2     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39602..54973 48017..49366 within 0


Gene organization within MGE regions


Location: 39602..54973
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MW_RS00165 (MW0031) mecA 39602..41611 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  MW_RS00170 (MW0032) - 41708..42694 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  MW_RS00175 - 42684..42926 (+) 243 Protein_32 type I restriction enzyme endonuclease domain-containing protein -
  MW_RS00180 (MW0034) - 42917..44527 (-) 1611 Protein_33 IS1182 family transposase -
  MW_RS00185 (MW0035) - 44576..45082 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  MW_RS00190 (MW0036) - 45097..45408 (-) 312 WP_000700851.1 DUF960 family protein -
  MW_RS00195 (MW0037) - 45495..45845 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  MW_RS00200 (MW0038) ccrB 46367..47995 (-) 1629 WP_001186600.1 cassette chromosome recombinase CcrB Machinery gene
  MW_RS00205 (MW0039) ccrA 48017..49366 (-) 1350 WP_000815641.1 cassette chromosome recombinase CcrA Machinery gene
  MW_RS00210 (MW0040) cch1 49600..51387 (-) 1788 WP_000122620.1 cassette chromosome replicative helicase -
  MW_RS00215 (MW0041) ssb 51387..51677 (-) 291 WP_001036438.1 cassette chromosome ssDNA-binding protein -
  MW_RS00220 (MW0042) - 51816..52865 (+) 1050 WP_000613248.1 hypothetical protein -
  MW_RS00225 (MW0043) - 53483..54973 (+) 1491 WP_000554504.1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52582.27 Da        Isoelectric Point: 10.0414

>NTDB_id=22080 MW_RS00205 WP_000815641.1 48017..49366(-) (ccrA) [Staphylococcus aureus subsp. aureus MW2]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQKQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQNTIQ
NIIQKRFTLNMLYPYIDEILITKSKTLMGIYFKNEPLNIVNQTTQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=22080 MW_RS00205 WP_000815641.1 48017..49366(-) (ccrA) [Staphylococcus aureus subsp. aureus MW2]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATTAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAAAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAAAACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATGCTGTATCCCTACATTGATGAAATTCTTATCACAAAAAGTAAAACACT
AATGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATCAAACAACGCAATCGTCAATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

95.546

100

0.955
  ccrA Staphylococcus aureus COL

76.169

100

0.762

Multiple sequence alignment