Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   BB197_RS02195 Genome accession   NZ_CP021863
Coordinates   357079..357720 (+) Length   213 a.a.
NCBI ID   WP_000357892.1    Uniprot ID   Q8E1N2
Organism   Streptococcus agalactiae strain SG-M163     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 352079..362720
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BB197_RS02175 (BB197_02175) - 352522..353259 (+) 738 WP_000406233.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  BB197_RS02180 (BB197_02180) pknB 353259..355214 (+) 1956 WP_017647742.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  BB197_RS02185 (BB197_02185) liaF 355375..356070 (+) 696 WP_000714456.1 cell wall-active antibiotics response protein LiaF -
  BB197_RS02190 (BB197_02190) - 356067..357086 (+) 1020 WP_000716170.1 sensor histidine kinase -
  BB197_RS02195 (BB197_02195) vraR 357079..357720 (+) 642 WP_000357892.1 response regulator transcription factor Regulator
  BB197_RS02200 (BB197_02200) - 357762..359162 (+) 1401 WP_000339133.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  BB197_RS02205 (BB197_02205) - 359164..359520 (+) 357 WP_000689608.1 S1 RNA-binding domain-containing protein -
  BB197_RS02210 (BB197_02210) - 359567..360343 (-) 777 WP_000180537.1 glycyl-radical enzyme activating protein -
  BB197_RS02215 (BB197_02215) - 360464..361219 (+) 756 WP_001080746.1 DeoR/GlpR family DNA-binding transcription regulator -
  BB197_RS02220 (BB197_02220) - 361338..362321 (+) 984 WP_000764455.1 sugar-binding transcriptional regulator -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23650.35 Da        Isoelectric Point: 5.0159

>NTDB_id=196866 BB197_RS02195 WP_000357892.1 357079..357720(+) (vraR) [Streptococcus agalactiae strain SG-M163]
MDKIKIVLVDDHEMVRLGLKSFLNLQADVEVIGEASNGLEGIKKALELRPDVVVMDLVMPEMDGVEATLALLKDWPEAAI
LVLTSYLDNEKIYPVIEAGAKGYMLKTSSAAEILNAIRKVSRGEQAIENEVDKKIKAHDKCPALHEGLTARERDILNLLA
KGYDNQRIADELFISLKTVKTHVSNILGKLNVADRTQAVVYAFQHHLVPQDDE

Nucleotide


Download         Length: 642 bp        

>NTDB_id=196866 BB197_RS02195 WP_000357892.1 357079..357720(+) (vraR) [Streptococcus agalactiae strain SG-M163]
ATGGATAAAATAAAAATTGTACTTGTTGATGACCATGAGATGGTTCGTCTCGGTTTAAAAAGTTTTTTAAACTTACAAGC
TGATGTTGAAGTAATAGGTGAGGCCTCAAATGGTTTAGAAGGCATAAAAAAAGCACTGGAGTTACGTCCAGACGTTGTTG
TTATGGACTTAGTAATGCCTGAAATGGACGGTGTAGAAGCAACCTTAGCATTATTGAAGGATTGGCCAGAAGCTGCCATT
TTAGTCTTAACATCTTACTTGGATAATGAAAAAATTTACCCTGTTATTGAAGCAGGTGCCAAAGGCTATATGTTAAAGAC
CTCAAGCGCAGCAGAGATTCTTAATGCCATTCGTAAAGTTTCAAGGGGAGAACAAGCTATTGAAAATGAAGTAGATAAGA
AAATTAAGGCTCATGATAAATGTCCAGCTTTACATGAGGGCTTAACAGCAAGGGAACGTGATATCCTTAATTTATTAGCC
AAAGGTTATGACAATCAAAGGATTGCTGATGAATTATTTATCTCGTTAAAGACTGTTAAAACTCATGTTTCTAATATTTT
GGGAAAACTAAATGTAGCAGATCGAACTCAAGCAGTTGTCTATGCTTTCCAACACCATTTGGTACCACAAGATGATGAAT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8E1N2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

54.854

96.714

0.531
  degU Bacillus subtilis subsp. subtilis str. 168

36.726

100

0.39

Multiple sequence alignment