Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   BFM96_RS05130 Genome accession   NZ_CP016953
Coordinates   1077845..1078582 (+) Length   245 a.a.
NCBI ID   WP_068991197.1    Uniprot ID   A0A917EFX9
Organism   Streptococcus himalayensis strain HTS2     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1072845..1083582
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BFM96_RS05100 - 1072913..1073416 (-) 504 WP_229676521.1 hypothetical protein -
  BFM96_RS10830 - 1073486..1073779 (-) 294 WP_083201745.1 helix-turn-helix transcriptional regulator -
  BFM96_RS05105 - 1073862..1074401 (+) 540 WP_068991181.1 DUF177 domain-containing protein -
  BFM96_RS05110 gndA 1074685..1076109 (+) 1425 WP_068991184.1 NADP-dependent phosphogluconate dehydrogenase -
  BFM96_RS05115 covR 1076118..1076807 (+) 690 WP_068991187.1 response regulator transcription factor Regulator
  BFM96_RS11340 - 1076917..1077303 (-) 387 WP_068991190.1 hypothetical protein -
  BFM96_RS05125 - 1077502..1077843 (+) 342 WP_068991194.1 LytTR family DNA-binding domain-containing protein -
  BFM96_RS05130 comE/blpR 1077845..1078582 (+) 738 WP_068991197.1 response regulator transcription factor Regulator
  BFM96_RS05135 - 1078596..1079933 (+) 1338 WP_068991199.1 GHKL domain-containing protein -
  BFM96_RS10840 - 1079984..1080142 (-) 159 WP_083201746.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  BFM96_RS05140 - 1080245..1081597 (-) 1353 WP_068991202.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28649.83 Da        Isoelectric Point: 6.5887

>NTDB_id=194037 BFM96_RS05130 WP_068991197.1 1077845..1078582(+) (comE/blpR) [Streptococcus himalayensis strain HTS2]
MDIFVLEDDFRQQTRLEQVIETLLEKHQIEPTYFDIFGKPDQLIHSIHQRGSHQVFFLDIEIKSEELKGLQVAKQIRAID
PYAIIVFVTTHSEFMPLSFRYQVSALDYIDKELSASEFESRIEAALLYAKSKEGKTIADDSFYFKSKYAQVQYPFEDVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQEKRLVQCHRSFAINPKNVVKVDRQAKLLYFPNGASCLIARQKMEGILSS
IEHLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=194037 BFM96_RS05130 WP_068991197.1 1077845..1078582(+) (comE/blpR) [Streptococcus himalayensis strain HTS2]
ATGGATATATTTGTATTGGAAGATGATTTTAGGCAACAAACCCGACTTGAGCAAGTGATTGAAACATTACTAGAGAAACA
TCAGATTGAGCCAACGTATTTTGATATTTTTGGAAAGCCTGATCAGTTGATTCATTCCATTCACCAGAGAGGTTCGCATC
AGGTATTTTTTTTGGATATTGAGATAAAGTCAGAAGAACTCAAAGGTCTTCAAGTTGCTAAACAGATTCGAGCAATTGAT
CCCTATGCAATTATTGTGTTTGTAACAACTCACTCTGAGTTTATGCCGTTATCATTTCGTTATCAAGTATCGGCATTGGA
TTATATCGATAAAGAATTATCTGCTAGTGAATTTGAATCTCGCATTGAAGCAGCTCTACTCTATGCAAAAAGTAAGGAGG
GTAAAACAATAGCTGATGATTCCTTTTATTTCAAATCGAAATATGCTCAGGTTCAATATCCTTTTGAAGACGTCTATTAT
ATAGAGACTTCTCCACGTCCTCATCGAGTTATTCTCTATACCAAGACTGACCGAATGGAATTTACCGCGAGCTTATCAGA
TATTCTAAAACAGGAGAAGAGGTTAGTGCAATGTCATCGTTCATTTGCTATCAATCCTAAGAATGTTGTCAAAGTGGACA
GGCAGGCTAAACTTCTCTATTTTCCTAATGGAGCAAGTTGTTTGATTGCACGACAAAAGATGGAGGGAATCTTGTCATCG
ATTGAGCATCTACACTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-236)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.893

98.776

0.522
  comE/comE1 Streptococcus equinus JB1

42.739

98.367

0.42
  comE/comE2 Streptococcus equinus JB1

38.934

99.592

0.388

Multiple sequence alignment