Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | BBD27_RS06225 | Genome accession | NZ_CP016394 |
| Coordinates | 1164807..1165883 (+) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain ND07 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1101709..1171201 | 1164807..1165883 | within | 0 |
Gene organization within MGE regions
Location: 1101709..1171201
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BBD27_RS05910 (BBD27_1156) | addA | 1102614..1106267 (+) | 3654 | WP_024703999.1 | helicase-exonuclease AddAB subunit AddA | - |
| BBD27_RS05915 (BBD27_1157) | - | 1106619..1107350 (-) | 732 | WP_014608678.1 | DUF554 domain-containing protein | - |
| BBD27_RS05920 (BBD27_1158) | - | 1107625..1108356 (+) | 732 | WP_002891761.1 | ABC transporter ATP-binding protein | - |
| BBD27_RS05925 (BBD27_1159) | - | 1108359..1109948 (+) | 1590 | WP_014608677.1 | ABC transporter permease | - |
| BBD27_RS05930 (BBD27_1160) | proB | 1110069..1110872 (+) | 804 | WP_014621941.1 | glutamate 5-kinase | - |
| BBD27_RS05935 (BBD27_1161) | - | 1110874..1112124 (+) | 1251 | WP_014621940.1 | glutamate-5-semialdehyde dehydrogenase | - |
| BBD27_RS05940 (BBD27_1162) | - | 1112458..1112748 (+) | 291 | WP_014621939.1 | hypothetical protein | - |
| BBD27_RS05945 (BBD27_1163) | - | 1112968..1113324 (+) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| BBD27_RS11480 | - | 1113598..1113741 (+) | 144 | WP_014621937.1 | hypothetical protein | - |
| BBD27_RS11750 | - | 1113815..1113946 (+) | 132 | WP_014621936.1 | hypothetical protein | - |
| BBD27_RS11485 (BBD27_1164) | - | 1113961..1114347 (+) | 387 | WP_011681587.1 | hypothetical protein | - |
| BBD27_RS11490 | - | 1114344..1114559 (+) | 216 | WP_011681586.1 | hypothetical protein | - |
| BBD27_RS11495 (BBD27_ps37) | - | 1114525..1114953 (+) | 429 | WP_011681585.1 | hypothetical protein | - |
| BBD27_RS05970 (BBD27_1165) | rsmH | 1115119..1116069 (+) | 951 | WP_014621931.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| BBD27_RS05975 (BBD27_1166) | ftsL | 1116072..1116392 (+) | 321 | WP_002948801.1 | cell division protein FtsL | - |
| BBD27_RS05980 (BBD27_1167) | pbp2X | 1116396..1118663 (+) | 2268 | WP_011681584.1 | penicillin-binding protein PBP2X | - |
| BBD27_RS05985 (BBD27_1168) | mraY | 1118665..1119687 (+) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| BBD27_RS05990 (BBD27_1169) | - | 1119762..1121105 (+) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| BBD27_RS05995 (BBD27_1171) | - | 1121953..1123308 (+) | 1356 | WP_002948886.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| BBD27_RS06000 (BBD27_1172) | - | 1123363..1124085 (+) | 723 | WP_024703996.1 | YutD family protein | - |
| BBD27_RS06005 (BBD27_1173) | rlmN | 1124089..1125258 (+) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| BBD27_RS06010 (BBD27_1174) | - | 1125260..1125787 (+) | 528 | WP_011226503.1 | VanZ family protein | - |
| BBD27_RS11500 (BBD27_1175) | - | 1125992..1126198 (+) | 207 | WP_002948879.1 | hypothetical protein | - |
| BBD27_RS06020 (BBD27_1176) | - | 1126386..1128143 (+) | 1758 | WP_024703995.1 | ABC transporter ATP-binding protein | - |
| BBD27_RS06025 (BBD27_1177) | - | 1128136..1129881 (+) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| BBD27_RS06030 (BBD27_ps38) | - | 1130895..1133047 (+) | 2153 | Protein_1122 | peptide cleavage/export ABC transporter | - |
| BBD27_RS06035 (BBD27_1180) | - | 1133063..1134430 (+) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| BBD27_RS06040 (BBD27_1181) | - | 1134445..1134606 (+) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| BBD27_RS11505 | - | 1134624..1135151 (-) | 528 | WP_231107203.1 | ATP-binding protein | - |
| BBD27_RS06050 (BBD27_1183) | - | 1135964..1136695 (-) | 732 | WP_002948869.1 | LytR/AlgR family response regulator transcription factor | - |
| BBD27_RS06055 (BBD27_1184) | - | 1136951..1137127 (+) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| BBD27_RS06060 (BBD27_1185) | - | 1137146..1137346 (+) | 201 | WP_011681569.1 | hypothetical protein | - |
| BBD27_RS06065 (BBD27_1186) | - | 1137702..1137932 (+) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| BBD27_RS11870 | - | 1138937..1139338 (+) | 402 | WP_024703992.1 | hypothetical protein | - |
| BBD27_RS06080 (BBD27_1189) | - | 1139589..1139843 (+) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| BBD27_RS06095 (BBD27_1192) | - | 1141750..1142442 (+) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| BBD27_RS06100 (BBD27_1193) | - | 1142473..1142679 (+) | 207 | WP_011681562.1 | hypothetical protein | - |
| BBD27_RS06105 (BBD27_1194) | - | 1142844..1143140 (+) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| BBD27_RS10780 | - | 1143462..1143725 (+) | 264 | WP_002945924.1 | hypothetical protein | - |
| BBD27_RS06110 | - | 1143850..1144230 (+) | 381 | WP_002951783.1 | hypothetical protein | - |
| BBD27_RS06115 (BBD27_1196) | - | 1144310..1146577 (-) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| BBD27_RS06120 (BBD27_1197) | gla | 1146698..1147561 (+) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| BBD27_RS06125 (BBD27_1198) | - | 1147648..1148010 (-) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| BBD27_RS06130 (BBD27_1199) | - | 1148292..1149047 (+) | 756 | WP_011681560.1 | CppA family protein | - |
| BBD27_RS06135 (BBD27_1200) | - | 1149047..1150003 (+) | 957 | WP_024703991.1 | serine hydrolase domain-containing protein | - |
| BBD27_RS06140 (BBD27_1202) | - | 1150206..1150856 (+) | 651 | WP_024703990.1 | ABC transporter ATP-binding protein | - |
| BBD27_RS06145 (BBD27_1203) | - | 1150853..1151608 (+) | 756 | WP_011681558.1 | ABC transporter permease | - |
| BBD27_RS11875 (BBD27_1204) | mobV | 1152053..1152561 (+) | 509 | Protein_1145 | MobV family relaxase | - |
| BBD27_RS06160 (BBD27_1205) | - | 1152586..1152891 (+) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| BBD27_RS06165 (BBD27_1206) | - | 1153242..1153694 (-) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| BBD27_RS06170 (BBD27_1207) | - | 1153745..1154527 (-) | 783 | WP_011681555.1 | carbonic anhydrase | - |
| BBD27_RS06175 (BBD27_1208) | pflB | 1154794..1157103 (-) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| BBD27_RS06180 (BBD27_1209) | dinB | 1157382..1158485 (+) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| BBD27_RS06185 (BBD27_1210) | - | 1158783..1159016 (+) | 234 | WP_002947030.1 | hypothetical protein | - |
| BBD27_RS06190 (BBD27_1211) | - | 1159476..1160306 (+) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| BBD27_RS06195 (BBD27_1212) | - | 1160694..1161440 (+) | 747 | WP_100284797.1 | amino acid ABC transporter permease | - |
| BBD27_RS06200 (BBD27_1213) | - | 1161440..1162183 (+) | 744 | WP_014608652.1 | amino acid ABC transporter ATP-binding protein | - |
| BBD27_RS06205 (BBD27_1214) | - | 1162398..1162622 (+) | 225 | WP_014621911.1 | DUF4059 family protein | - |
| BBD27_RS06210 (BBD27_1215) | trxB | 1162655..1163608 (+) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| BBD27_RS06215 (BBD27_1216) | rsmD | 1163699..1164298 (+) | 600 | Protein_1157 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| BBD27_RS06220 (BBD27_1217) | coaD | 1164332..1164829 (+) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| BBD27_RS06225 (BBD27_1218) | sepM | 1164807..1165883 (+) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| BBD27_RS06230 (BBD27_1219) | - | 1165968..1166912 (+) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| BBD27_RS06235 (BBD27_1220) | - | 1166909..1167457 (+) | 549 | WP_011226462.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| BBD27_RS06240 (BBD27_1221) | - | 1167454..1167696 (+) | 243 | WP_011226461.1 | hypothetical protein | - |
| BBD27_RS06245 (BBD27_1222) | - | 1167705..1169771 (+) | 2067 | WP_011681548.1 | cation:proton antiporter | - |
| BBD27_RS06250 (BBD27_1223) | - | 1170393..1171175 (-) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=187851 BBD27_RS06225 WP_011681549.1 1164807..1165883(+) (sepM) [Streptococcus thermophilus strain ND07]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=187851 BBD27_RS06225 WP_011681549.1 1164807..1165883(+) (sepM) [Streptococcus thermophilus strain ND07]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |