Detailed information NTG0182976

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLJM2_RS08320
• Genome accession: NZ_CP015900
• Coordinates: 1620910..1621602 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain JM2
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1615910..1626602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLJM2_RS08300 (LLJM2_1627)	murD	1616054..1617403 (-)	1350	WP_081196782.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLJM2_RS08305 (LLJM2_1628)	-	1617572..1617913 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLJM2_RS08310 (LLJM2_1629)	-	1617998..1619239 (-)	1242	WP_015082643.1	ammonium transporter	-
LLJM2_RS08315 (LLJM2_1630)	covS	1619425..1620897 (-)	1473	WP_081196783.1	HAMP domain-containing histidine kinase	Regulator
LLJM2_RS08320 (LLJM2_1631)	covR	1620910..1621602 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLJM2_RS08325 (LLJM2_1632)	-	1621759..1622289 (-)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLJM2_RS08330 (LLJM2_1633)	-	1622422..1622667 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLJM2_RS08335 (LLJM2_1634)	-	1622991..1623353 (-)	363	Protein_1617	TIGR02328 family protein	-
LLJM2_RS08340 (LLJM2_03305)	-	1623590..1624501 (-)	912	Protein_1618	CHAP domain-containing protein	-
LLJM2_RS08345 (LLJM2_1637)	-	1624594..1625430 (-)	837	WP_021165524.1	metallophosphoesterase	-
LLJM2_RS08350 (LLJM2_1638)	arsC	1625542..1625946 (-)	405	WP_021165525.1	arsenate reductase (thioredoxin)	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=182976 LLJM2_RS08320 WP_011676631.1 1620910..1621602(-) (covR) [Lactococcus cremoris strain JM2]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=182976 LLJM2_RS08320 WP_011676631.1 1620910..1621602(-) (covR) [Lactococcus cremoris strain JM2]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACTGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361