Detailed information NTG0145758

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SpyM6JRS4_RS05795
• Genome accession: NZ_CP011414
• Coordinates: 1162729..1163766 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes JRS4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1157729..1168766

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SpyM6JRS4_RS05775 (SpyM6JRS4_05770)	-	1158478..1159104 (+)	627	WP_011184760.1	A24 family peptidase	-
SpyM6JRS4_RS05780 (SpyM6JRS4_05775)	rlmN	1159186..1160265 (-)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SpyM6JRS4_RS05785 (SpyM6JRS4_05780)	-	1160269..1160889 (-)	621	WP_002992791.1	YutD family protein	-
SpyM6JRS4_RS05790 (SpyM6JRS4_05785)	-	1161337..1162313 (-)	977	Protein_1116	LacI family DNA-binding transcriptional regulator	-
SpyM6JRS4_RS05795 (SpyM6JRS4_05790)	sepM	1162729..1163766 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SpyM6JRS4_RS05800 (SpyM6JRS4_05795)	coaD	1163753..1164244 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SpyM6JRS4_RS05805 (SpyM6JRS4_05800)	rsmD	1164234..1164773 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SpyM6JRS4_RS05810 (SpyM6JRS4_05805)	asnA	1164896..1165888 (-)	993	WP_011184764.1	aspartate--ammonia ligase	-
SpyM6JRS4_RS05815 (SpyM6JRS4_05810)	arcC	1166201..1167151 (-)	951	WP_011018011.1	carbamate kinase	-
SpyM6JRS4_RS05820 (SpyM6JRS4_05815)	-	1167171..1168502 (-)	1332	WP_011184765.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=145758 SpyM6JRS4_RS05795 WP_010922499.1 1162729..1163766(-) (sepM) [Streptococcus pyogenes JRS4]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=145758 SpyM6JRS4_RS05795 WP_010922499.1 1162729..1163766(-) (sepM) [Streptococcus pyogenes JRS4]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693