Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SpyM6JRS4_RS06450 Genome accession   NZ_CP011414
Coordinates   1277482..1278123 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes JRS4     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1272482..1283123
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SpyM6JRS4_RS06425 (SpyM6JRS4_06420) comFA/cflA 1272568..1273893 (-) 1326 WP_011184811.1 DEAD/DEAH box helicase Machinery gene
  SpyM6JRS4_RS06430 (SpyM6JRS4_06425) - 1273949..1274581 (+) 633 WP_009880468.1 YigZ family protein -
  SpyM6JRS4_RS06435 (SpyM6JRS4_06430) cysK 1274709..1275650 (+) 942 WP_011184813.1 cysteine synthase A -
  SpyM6JRS4_RS06440 (SpyM6JRS4_06435) - 1275668..1276045 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  SpyM6JRS4_RS06445 (SpyM6JRS4_06440) - 1276045..1277445 (-) 1401 WP_011888672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  SpyM6JRS4_RS06450 (SpyM6JRS4_06445) vraR 1277482..1278123 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  SpyM6JRS4_RS06455 (SpyM6JRS4_06450) - 1278116..1279120 (-) 1005 WP_011184815.1 sensor histidine kinase -
  SpyM6JRS4_RS06460 (SpyM6JRS4_06455) liaF 1279117..1279809 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  SpyM6JRS4_RS06465 (SpyM6JRS4_06460) pknB 1279932..1281830 (-) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SpyM6JRS4_RS06470 (SpyM6JRS4_06465) - 1281827..1282567 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=127945 SpyM6JRS4_RS06450 WP_002983671.1 1277482..1278123(-) (vraR) [Streptococcus pyogenes JRS4]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=127945 SpyM6JRS4_RS06450 WP_002983671.1 1277482..1278123(-) (vraR) [Streptococcus pyogenes JRS4]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTGTCAAAGGGAGAGCTAGCCATTGAAACAGAGGTAGACAAAA
AAATTAAAGCGCATGACCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment