Detailed information NTG0120954

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DK93_RS06285
• Genome accession: NZ_CP007562
• Coordinates: 1285718..1287070 (-)
• Length: 450 a.a.
• NCBI ID: WP_002985643.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NGAS327
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1280718..1292070

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK93_RS06275 (DK93_06460)	rnc	1283781..1284473 (-)	693	WP_002985639.1	ribonuclease III	-
DK93_RS06280 (DK93_06465)	vicX	1284905..1285714 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DK93_RS06285 (DK93_06470)	vicK	1285718..1287070 (-)	1353	WP_002985643.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DK93_RS06290 (DK93_06475)	vicR	1287063..1287773 (-)	711	WP_002985645.1	response regulator YycF	Regulator
DK93_RS06295 (DK93_06480)	-	1287935..1288969 (-)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
DK93_RS06300 (DK93_06485)	-	1289025..1290272 (-)	1248	WP_009880281.1	AMP-binding protein	-
DK93_RS06305 (DK93_06490)	-	1290229..1291377 (-)	1149	WP_009880280.1	acetyl-CoA C-acyltransferase	-
DK93_RS06310 (DK93_06495)	-	1291772..1291921 (-)	150	WP_011285429.1	hypothetical protein	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51439.91 Da
• Isoelectric Point: 5.5556

>NTDB_id=120954 DK93_RS06285 WP_002985643.1 1285718..1287070(-) (vicK) [Streptococcus pyogenes strain NGAS327]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRYLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=120954 DK93_RS06285 WP_002985643.1 1285718..1287070(-) (vicK) [Streptococcus pyogenes strain NGAS327]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGATACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAAACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• PAS fold (PAS) (95-162)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638