Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   RG62_RS12470 Genome accession   NZ_CP010219
Coordinates   2360063..2360695 (+) Length   210 a.a.
NCBI ID   WP_000242755.1    Uniprot ID   A0A1C4FZU4
Organism   Escherichia coli strain M18     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2355063..2365695
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RG62_RS12440 (RG62_11775) yheS 2355232..2357145 (+) 1914 WP_000634798.1 ABC transporter ATP-binding protein -
  RG62_RS12445 (RG62_11780) yheT 2357145..2358167 (+) 1023 WP_000057405.1 hydrolase -
  RG62_RS12450 (RG62_11785) yheU 2358161..2358379 (+) 219 WP_000907085.1 YheU family protein -
  RG62_RS12455 (RG62_11790) prkB 2358433..2359302 (+) 870 WP_001274680.1 phosphoribulokinase -
  RG62_RS12460 (RG62_11795) yhfA 2359357..2359761 (-) 405 WP_001148908.1 OsmC family protein -
  RG62_RS12470 (RG62_11805) crp 2360063..2360695 (+) 633 WP_000242755.1 cAMP-activated global transcriptional regulator CRP Regulator
  RG62_RS12475 (RG62_11810) yhfK 2360746..2362836 (+) 2091 WP_001543189.1 YccS/YhfK family membrane protein -
  RG62_RS12480 (RG62_11815) argD 2362903..2364123 (-) 1221 WP_000963785.1 bifunctional acetylornithine/succinyldiaminopimelate transaminase -
  RG62_RS12485 (RG62_11820) pabA 2364209..2364772 (-) 564 WP_000601847.1 aminodeoxychorismate synthase component 2 -
  RG62_RS12490 (RG62_11825) fic 2364804..2365406 (-) 603 WP_001280624.1 putative adenosine monophosphate-protein transferase Fic -
  RG62_RS12495 (RG62_11830) yhfG 2365396..2365563 (-) 168 WP_000736860.1 YhfG family protein -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23640.43 Da        Isoelectric Point: 8.2710

>NTDB_id=118044 RG62_RS12470 WP_000242755.1 2360063..2360695(+) (crp) [Escherichia coli strain M18]
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG
QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTH
PDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Nucleotide


Download         Length: 633 bp        

>NTDB_id=118044 RG62_RS12470 WP_000242755.1 2360063..2360695(+) (crp) [Escherichia coli strain M18]
ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAA
GAGCACGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAG
ACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGC
CAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGAT
TCAGGTAAACCCGGACATTCTGATGCGTCTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCA
ACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAACCTGGCAAAACAACCAGATGCTATGACTCAC
CCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATCGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCAT
TCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTTAA

Domains

Predicted by InterProScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(23-109)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(142-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1C4FZU4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Vibrio cholerae strain A1552

95.714

100

0.957
  crp Haemophilus influenzae Rd KW20

77.941

97.143

0.757
  crp Acinetobacter baumannii D1279779

47.343

98.571

0.467

Multiple sequence alignment