Detailed information NTG1154847

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: OOL12_RS10650
• Genome accession: NZ_OX344719
• Coordinates: 2105255..2106604 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815640.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain ST20190863 isolate ST20190863
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2100084..2115019	2105255..2106604	within	0

Gene organization within MGE regions

Location: 2100084..2115019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OOL12_RS10630	-	2100084..2101238 (-)	1155	WP_000912116.1	ATP-binding protein	-
OOL12_RS10635	-	2101693..2102739 (+)	1047	WP_001042023.1	hypothetical protein	-
OOL12_RS10640	ssb	2102932..2103228 (+)	297	WP_000273823.1	cassette chromosome ssDNA-binding protein	-
OOL12_RS10645	cch1	2103228..2105021 (+)	1794	WP_000079473.1	cassette chromosome replicative helicase	-
OOL12_RS10650	ccrA	2105255..2106604 (+)	1350	WP_000815640.1	cassette chromosome recombinase CcrA	Machinery gene
OOL12_RS10655	ccrB	2106626..2108254 (+)	1629	WP_001186608.1	cassette chromosome recombinase CcrB	Machinery gene
OOL12_RS10660	-	2108776..2109126 (+)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
OOL12_RS10665	-	2109213..2109524 (+)	312	WP_000700851.1	DUF960 family protein	-
OOL12_RS10670	-	2109539..2110045 (+)	507	WP_001092194.1	DUF1643 domain-containing protein	-
OOL12_RS10675	-	2110094..2111704 (+)	1611	Protein_2068	IS1182 family transposase	-
OOL12_RS10680	-	2111695..2111937 (-)	243	Protein_2069	type I restriction enzyme endonuclease domain-containing protein	-
OOL12_RS10685	-	2111927..2112913 (-)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
OOL12_RS10690	mecA	2113010..2115019 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52663.34 Da
• Isoelectric Point: 9.9639

>NTDB_id=1154847 OOL12_RS10650 WP_000815640.1 2105255..2106604(+) (ccrA) [Staphylococcus aureus strain ST20190863 isolate ST20190863]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1154847 OOL12_RS10650 WP_000815640.1 2105255..2106604(+) (ccrA) [Staphylococcus aureus strain ST20190863 isolate ST20190863]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Recombinase (Recombinase) (169-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	97.55	100	0.976
ccrA	Staphylococcus aureus COL	75.947	100	0.759