Detailed information NTG1154813

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OOL12_RS00455
• Genome accession: NZ_OX344719
• Coordinates: 82560..83603 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ST20190863 isolate ST20190863
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77560..88603

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OOL12_RS00425	-	77871..77981 (+)	111	WP_001790257.1	hypothetical protein	-
OOL12_RS00430	-	78010..78423 (+)	414	WP_078162883.1	hypothetical protein	-
OOL12_RS00435	-	78913..79899 (-)	987	WP_000999713.1	FUSC family protein	-
OOL12_RS00440	map	80486..81244 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OOL12_RS00445	-	81461..81847 (+)	387	WP_001110179.1	hypothetical protein	-
OOL12_RS00450	liaF	81862..82563 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OOL12_RS00455	vraS	82560..83603 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OOL12_RS00460	vraR	83593..84222 (+)	630	WP_264717416.1	two-component system response regulator VraR	Regulator
OOL12_RS00465	-	84338..85555 (-)	1218	WP_061732697.1	YihY/virulence factor BrkB family protein	-
OOL12_RS00470	-	85833..86108 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
OOL12_RS00475	-	86115..86579 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OOL12_RS00480	-	86726..86926 (+)	201	WP_000180461.1	DUF1128 family protein	-
OOL12_RS00485	-	86929..88185 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1154813 OOL12_RS00455 WP_001017131.1 82560..83603(+) (vraS) [Staphylococcus aureus strain ST20190863 isolate ST20190863]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1154813 OOL12_RS00455 WP_001017131.1 82560..83603(+) (vraS) [Staphylococcus aureus strain ST20190863 isolate ST20190863]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1