Detailed information NTG1150146

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DXE38_RS13100
• Genome accession: NZ_LT992477
• Coordinates: 2559165..2560208 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus isolate 22_LA_562
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2554165..2565208

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DXE38_RS13065	-	2554780..2554890 (+)	111	WP_014937049.1	hypothetical protein	-
DXE38_RS13070	-	2554919..2555332 (+)	414	WP_025174370.1	hypothetical protein	-
DXE38_RS13075	-	2555521..2556507 (-)	987	WP_000999712.1	FUSC family protein	-
DXE38_RS13085	map	2557091..2557849 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
DXE38_RS13090	-	2558066..2558452 (+)	387	WP_001110182.1	hypothetical protein	-
DXE38_RS13095	liaF	2558467..2559168 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DXE38_RS13100	vraS	2559165..2560208 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DXE38_RS13105	vraR	2560198..2560827 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DXE38_RS13110	-	2560940..2562157 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
DXE38_RS13115	-	2562435..2562710 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
DXE38_RS13120	-	2562717..2563181 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DXE38_RS13125	-	2563328..2563528 (+)	201	WP_000180460.1	DUF1128 family protein	-
DXE38_RS13130	-	2563531..2564787 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1150146 DXE38_RS13100 WP_001017131.1 2559165..2560208(+) (vraS) [Staphylococcus aureus isolate 22_LA_562]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1150146 DXE38_RS13100 WP_001017131.1 2559165..2560208(+) (vraS) [Staphylococcus aureus isolate 22_LA_562]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1