Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LLA12_RS11800 Genome accession   NZ_LT599049
Coordinates   2399261..2400487 (+) Length   408 a.a.
NCBI ID   WP_021721857.1    Uniprot ID   S6F484
Organism   Lactococcus lactis subsp. lactis strain A12     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2394261..2405487
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLA12_RS11775 (LLA12_02496) - 2395353..2396156 (-) 804 WP_021721861.1 phosphatidate cytidylyltransferase -
  LLA12_RS11780 (LLA12_02497) - 2396156..2396890 (-) 735 WP_003130589.1 isoprenyl transferase -
  LLA12_RS11785 (LLA12_02498) yajC 2397262..2397594 (-) 333 WP_021721860.1 preprotein translocase subunit YajC -
  LLA12_RS11790 (LLA12_02500) - 2397689..2398387 (-) 699 WP_021721859.1 DNA alkylation repair protein -
  LLA12_RS11795 (LLA12_02501) rlmH 2398406..2398885 (-) 480 WP_021721858.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LLA12_RS11800 (LLA12_02502) htrA 2399261..2400487 (+) 1227 WP_021721857.1 S1C family serine protease Regulator
  LLA12_RS11805 (LLA12_02503) - 2400613..2401611 (+) 999 WP_021721856.1 glycosyltransferase family 4 protein -
  LLA12_RS11810 (LLA12_02504) - 2401737..2403077 (+) 1341 WP_021721855.1 glycosyltransferase family 4 protein -
  LLA12_RS11815 (LLA12_02505) - 2403185..2403409 (+) 225 WP_003130579.1 YkuJ family protein -
  LLA12_RS11820 (LLA12_02506) - 2403545..2404549 (+) 1005 WP_021721854.1 hypothetical protein -
  LLA12_RS11825 (LLA12_02507) - 2404590..2405342 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41678.04 Da        Isoelectric Point: 4.9853

>NTDB_id=1144894 LLA12_RS11800 WP_021721857.1 2399261..2400487(+) (htrA) [Lactococcus lactis subsp. lactis strain A12]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKEVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=1144894 LLA12_RS11800 WP_021721857.1 2399261..2400487(+) (htrA) [Lactococcus lactis subsp. lactis strain A12]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATTGGCAAATAATAGTCGTTCAAATACAACTAGCACAAAGGTTAGTAACGTTTCAGTAAATG
TCAACACCGATGTTACCTCTGCGATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGTGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGAGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGTT
CACTCGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGAAGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCTAATACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAACGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGGCAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCCAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGATAGTTCACAATTGAAATTACCAAGT
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCCGGCTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAACACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(223-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S6F484

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

53.279

89.706

0.478

Multiple sequence alignment