Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   EL086_RS04995 Genome accession   NZ_LR134274
Coordinates   1009238..1010581 (+) Length   447 a.a.
NCBI ID   WP_038675887.1    Uniprot ID   A0A448AAV4
Organism   Streptococcus salivarius strain NCTC8618     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1004238..1015581
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL086_RS04965 (NCTC8618_03415) - 1004297..1005064 (-) 768 WP_060775856.1 amino acid ABC transporter ATP-binding protein -
  EL086_RS04970 (NCTC8618_03416) - 1005250..1005900 (-) 651 WP_002886253.1 amino acid ABC transporter permease -
  EL086_RS04975 (NCTC8618_03417) - 1005912..1006610 (-) 699 WP_002886251.1 amino acid ABC transporter permease -
  EL086_RS04980 (NCTC8618_03418) - 1006628..1007461 (-) 834 WP_037611665.1 transporter substrate-binding domain-containing protein -
  EL086_RS04985 (NCTC8618_03419) - 1007471..1008238 (-) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  EL086_RS04990 (NCTC8618_03420) vicR 1008538..1009245 (+) 708 WP_002884978.1 response regulator YycF Regulator
  EL086_RS04995 (NCTC8618_03421) vicK 1009238..1010581 (+) 1344 WP_038675887.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EL086_RS05000 (NCTC8618_03422) vicX 1010587..1011396 (+) 810 WP_126405093.1 MBL fold metallo-hydrolase Regulator
  EL086_RS05005 (NCTC8618_03423) - 1011455..1011814 (+) 360 WP_037611660.1 YbaN family protein -
  EL086_RS05010 (NCTC8618_03424) - 1011866..1013080 (-) 1215 WP_038675892.1 aminoacyltransferase -
  EL086_RS05015 (NCTC8618_03425) yidA 1013082..1013891 (-) 810 WP_002890845.1 sugar-phosphatase -
  EL086_RS05020 (NCTC8618_03426) - 1014069..1014935 (+) 867 WP_038675894.1 GNAT family N-acetyltransferase -
  EL086_RS05025 (NCTC8618_03427) - 1015018..1015404 (+) 387 WP_002884910.1 DUF1934 domain-containing protein -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 51002.17 Da        Isoelectric Point: 4.9199

>NTDB_id=1119821 EL086_RS04995 WP_038675887.1 1009238..1010581(+) (vicK) [Streptococcus salivarius strain NCTC8618]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYRQVKNIRKLTKRVKSLMAGNYNEELRLKGDPELLELADSLNDLSDV
FRLTHENLAQEKNRLSSVLSYMSDGVIATNRRGQITMINSTAQRLLNLDFETATQMSILDLLDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALNE
DIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLDVEMTNFTAFMTYILNRFDQIKSQESNTGKTYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGEITVSMKTTDSQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAMMVDEWEME

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=1119821 EL086_RS04995 WP_038675887.1 1009238..1010581(+) (vicK) [Streptococcus salivarius strain NCTC8618]
ATGACTAGTATTGGCTTAAACATCACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTTTTTGTGGCTTTCTACTTTAT
TTTTCTTGCTTATCGTGATTATCGACAAGTCAAAAATATTCGAAAGTTGACCAAGAGGGTCAAGTCCTTAATGGCAGGTA
ACTATAATGAGGAGTTACGTTTAAAGGGTGATCCAGAGCTTTTAGAGCTAGCTGATAGCTTAAATGATTTATCGGACGTC
TTTCGTTTGACACATGAAAATCTAGCCCAGGAAAAAAACCGCTTATCATCAGTCCTCTCTTACATGAGTGATGGAGTCAT
TGCGACAAATCGTCGTGGTCAAATTACCATGATTAATAGCACAGCTCAGCGTTTGTTGAATCTAGATTTTGAGACAGCGA
CACAGATGTCCATTTTAGACTTATTAGATGGTGAAAATCCCTACACCTATAGTGAATTGCTGTCTAAGACTCCTGAAATT
CATTTGTCTCGTCGAGATGCCAACGATGAATTTGTGACCTTACGCGTTAACTTTGCTCTTATTCGTAAAGAGTCTGGATT
CATTTCAGGTCTGGTTGCCGTTCTTCATGATGCTACTGAGCAGGAAAAAGAAGAGCGTGAACGTCGTCTATTTGTTTCAA
ACGTTAGTCACGAGTTGCGTACACCTCTGACTTCTGTAAAATCTTATCTAGAGGCACTTGATGATGGAGCTCTCAACGAA
GATATCGCCCCTAACTTTATCAAAGTTTCGCTAGATGAGACCAATCGTATGATGCGAATGATTTCTGACCTCTTGGCACT
TTCTCGTATTGACAATAAGAGCACTCAACTTGATGTTGAAATGACTAATTTCACGGCCTTCATGACCTATATCTTGAATC
GTTTTGATCAAATCAAAAGTCAAGAAAGCAATACTGGTAAGACGTACGAAATTATTCGAGATTACCCTGTAAATTCTATT
TGGGTGGAGATTGATACGGATAAGATGACTCAGGTCGTGGATAATATTCTTAACAATGCCATCAAGTATTCTCCTGATGG
TGGTGAGATTACAGTGTCCATGAAGACAACTGATTCACAGTTGATTGTTTCTATTTCTGACCAAGGTTTAGGTATCCCTA
AGAAAGATTTACCTTTGATTTTCGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCCCAGGGTGGAACGGGTCTA
GGCTTGTCCATTGCCAAAGAGATTATTAAACAACATAAGGGCTTCATTTGGGCTAAGAGTGAGTATGGTAAGGGTTCAAC
ATTTACAATTGTGCTTCCATATGACAAGGATGCCATGATGGTTGATGAATGGGAGATGGAGTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

PAS fold (PAS)

(94-197)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A448AAV4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.671

92.617

0.682
  micB Streptococcus pneumoniae Cp1015

67.436

96.868

0.653

Multiple sequence alignment