Detailed information NTG1004976

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FGL00_RS09905
• Genome accession: NZ_LR594034
• Coordinates: 1982006..1982746 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1977006..1987746

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL00_RS09875 (NCTC8546_02036)	-	1977904..1978608 (-)	705	WP_048327178.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
FGL00_RS09885 (NCTC8546_02037)	rpmH	1978939..1979073 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
FGL00_RS09890 (NCTC8546_02038)	jag	1979386..1980300 (-)	915	WP_003062632.1	RNA-binding cell elongation regulator Jag/EloR	-
FGL00_RS09895 (NCTC8546_02039)	-	1980312..1981139 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
FGL00_RS09900 (NCTC8546_02040)	rnpA	1981105..1981464 (-)	360	WP_003056083.1	ribonuclease P protein component	-
FGL00_RS09905 (NCTC8546_02041)	comE/blpR	1982006..1982746 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
FGL00_RS09910 (NCTC8546_02042)	-	1982750..1984033 (-)	1284	WP_138084048.1	sensor histidine kinase	-
FGL00_RS09915 (NCTC8546_02043)	-	1984034..1985377 (-)	1344	WP_048327180.1	GHKL domain-containing protein	-
FGL00_RS09920 (NCTC8546_02044)	gltX	1985992..1987440 (-)	1449	WP_003053372.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=1004976 FGL00_RS09905 WP_003061418.1 1982006..1982746(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=1004976 FGL00_RS09905 WP_003061418.1 1982006..1982746(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTCTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394