Detailed information NTG1002116

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL147_RS06920
• Genome accession: NZ_LR134341
• Coordinates: 1414643..1415380 (+)
• Length: 245 a.a.
• NCBI ID: WP_007892591.1
• Uniprot ID: G5K876
• Organism: Streptococcus pseudoporcinus strain NCTC13786
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1409643..1420380

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL147_RS06905 (NCTC13786_01388)	gltX	1410182..1411627 (+)	1446	WP_007892565.1	glutamate--tRNA ligase	-
EL147_RS06910 (NCTC13786_01389)	-	1411988..1413334 (+)	1347	WP_007892385.1	GHKL domain-containing protein	-
EL147_RS06915 (NCTC13786_01390)	-	1413334..1414641 (+)	1308	WP_007892267.1	hypothetical protein	-
EL147_RS06920 (NCTC13786_01391)	comE/blpR	1414643..1415380 (+)	738	WP_007892591.1	LytTR family DNA-binding domain-containing protein	Regulator
EL147_RS06925 (NCTC13786_01392)	rnpA	1416220..1416579 (+)	360	WP_007892570.1	ribonuclease P protein component	-
EL147_RS06930 (NCTC13786_01393)	-	1416563..1417375 (+)	813	WP_007892348.1	YidC/Oxa1 family membrane protein insertase	-
EL147_RS06935 (NCTC13786_01394)	jag	1417391..1418350 (+)	960	WP_007892561.1	RNA-binding cell elongation regulator Jag/EloR	-
EL147_RS06945 (NCTC13786_01395)	rpmH	1419699..1419833 (+)	135	WP_000831903.1	50S ribosomal protein L34	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28837.12 Da
• Isoelectric Point: 5.2197

>NTDB_id=1002116 EL147_RS06920 WP_007892591.1 1414643..1415380(+) (comE/blpR) [Streptococcus pseudoporcinus strain NCTC13786]
MNIFILEDDYIQQGRIESVIEEILKEQKIAKSYMEVFSNPQKLLDSIHERGEHQLFFLDIDIKGETKRGLELAAEIRMLD
SNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDNAQFKEQIQECILYTRQMMSNHETEEVFLFETPQTRLRLPYKDILY
FATSTTPHKVCLWTQTERLEFYGNLAELQEVAPKLFLCHRSFLVNLENVVRIDKSHQLVYFENGDSCLVSRLKIKHLIEK
WESFN

Nucleotide

• Length: 738 bp

>NTDB_id=1002116 EL147_RS06920 WP_007892591.1 1414643..1415380(+) (comE/blpR) [Streptococcus pseudoporcinus strain NCTC13786]
ATGAATATTTTTATATTAGAAGACGACTATATCCAACAGGGCCGGATAGAGTCTGTTATTGAAGAGATTTTAAAAGAGCA
GAAGATCGCGAAATCTTATATGGAGGTTTTTTCTAATCCACAAAAGCTCCTAGATAGTATTCATGAACGTGGAGAGCATC
AACTTTTTTTCTTAGATATTGATATCAAAGGCGAAACAAAAAGGGGATTAGAATTAGCAGCGGAGATTCGGATGTTAGAT
TCTAATGCTGTTATTGTGTTCGTTACGACCCACTCTGAATTTGCACCTATTTCATTCAAATATAAGGTTTCAGCACTTGA
TTTTATTGATAAAGCTGTTGACAATGCCCAATTTAAAGAACAAATTCAAGAATGTATCCTCTATACAAGACAGATGATGT
CAAACCATGAGACAGAAGAAGTATTTTTATTTGAAACGCCTCAAACTCGTCTTCGGTTACCCTATAAAGATATTTTATAT
TTTGCCACCTCGACAACTCCCCATAAAGTCTGCCTTTGGACTCAGACAGAACGTTTAGAATTTTATGGTAATTTAGCAGA
ACTTCAAGAAGTTGCCCCCAAACTATTTCTTTGTCATCGTTCATTTTTAGTGAATTTGGAAAATGTAGTGCGAATAGACA
AATCTCATCAATTGGTCTATTTTGAAAATGGGGATTCCTGCCTAGTTTCGCGTTTGAAAATAAAGCATTTAATCGAAAAA
TGGGAATCATTTAACTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: G5K876

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	48.739	97.143	0.473
comE/comE1	Streptococcus equinus JB1	44.118	97.143	0.429
comE/comE2	Streptococcus gordonii strain NCTC7865	40.8	100	0.416
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.8	100	0.416
comE/comE2	Streptococcus equinus JB1	40.984	99.592	0.408
comE	Streptococcus infantis strain Atu-4	38.589	98.367	0.38
comE	Streptococcus mitis NCTC 12261	38.174	98.367	0.376
comE	Streptococcus pneumoniae Rx1	38.174	98.367	0.376
comE	Streptococcus pneumoniae D39	38.174	98.367	0.376
comE	Streptococcus pneumoniae R6	38.174	98.367	0.376
comE	Streptococcus pneumoniae TIGR4	38.174	98.367	0.376
comE	Streptococcus mitis SK321	38.174	98.367	0.376