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报告题目:Histidine kinase: the receptor of β-lactam antibiotics in Gram negative bacteria

报 告 人:Dr. Xiaohui Zhou
Assistant Professor
Department of Pathobiology
University of Connecticut
报告时间:10月27日(星期四) 9:00-10:00
报告地点:徐汇校区哲生馆一楼会议室
联 系 人:欧竑宇 hyou@sjtu.edu.cn

报告摘要:
Bacteria can produce β-lactamases, enzymes that destroy β-lactam antibiotics and thereby resist these potent antibiotics that target cell wall synthesis. Production of β-lactamases is often controlled by β-lactam-induced perturbations in the cell wall. Here, we have identified a new mechanism controlling β-lactamase production. We found a signaling system in which a membrane-associated histidine kinase directly binds β-lactams, triggering the expression of a β-lactamase and resistance to β-lactam antibiotics. Direct sensing of β-lactam antibiotics may enable sufficiently rapid induction of β-lactamase to degrade β-lactam antibiotics before the integrity of the cell wall is disturbed.


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