TADB: a web-based resource for Type 2 toxin-antitoxin loci in Bacteria and Archaea

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Toxin-antitoxin (TA) loci play a role in bacterial stress physiology and the stabilisation of horizontally acquired elements. TA loci are found abundantly distributed among free-living Bacteria and Archaea. TA loci code for a stable toxin that is neutralized by a short-lived antitoxin. The antitoxin can be either an antisense RNA (Type 1 TA loci) or a protein (Type 2 TA loci). To date numerous distinct Type 2 TA families have been reported.

The aim of this PostgreSQL-based TADB database is to create and maintain a resource of all currently available Type 2 TA loci-relevant data ranging from 'wet' experimental data to information garnered by bioinformatics analyses. We offer TADB as a 'one-stop-shop' for ease of access to all Type 2 TA resources. Importantly, we aim to continue to further develop TADB substantially over the years ahead, both through our own initiatives and in response to user suggestions and work patterns, and are confident that TADB will facilitate efficient investigation of the many molecular, biological, cellular and evolutionary processes that relate to these mysterious but near-ubiquitous prokaryotic systems.

Reference: Y. Shao, E.M. Harrison, D. Bi, C. Tai, X. He, H.Y. Ou, K. Rajakumar and Z. Deng (2011) TADB: a web-based resource for Type 2 toxin-antitoxin loci in Bacteria and Archaea. Nucleic Acids Research, 39, D606-D611. [Abstract]

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