SecReT4
Effector Protein ID: 52843057
T4SS name [ID]Dot/Icm [5]
Gene symbollegC8
Locus taglpg2862
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]3237892..3239802 [-]
Productcoiled-coil containing protein
Effector typeProtein
DescriptonLgt2/legC8
T4CP requirementT4CP Depedent
Target/EffectionLgt2 is necessary for egress of Legionella from the host cell. (Belyi, et al. 2011)
UniProt IDQ5ZRL9
KEGG IDlpn:lpg2862
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 636 a.a.     [Download]
>gi|52843057|ref|YP_096856.1| coiled-coil containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MSEQYWRFKLMTEGGCNQNEATRLITVLKRKLKPFPEESINKLFENDNFCNRLSSYMAYGFGAAEEWIKK
QQILSNIQPLTSEQRVDITPEKDTVSDNKPNIFGAAITFGKSPVVKLLKQNAREICESILMDEPNLKQVE
YIFRLLALQVQETYSGEQAEKLYECIRDKKPIPSKFEEILLPIVNRIKENHTEILNESKRNHLGVTIQLN
DPYSFSTKNSFCIWFSNNPNSAMPKKIKDILEERAKQNAPGVTKLVYSRACLTKKENTNFVQWAKENGIT
LLDFDELKCQGEDLELWNLAQAELKAMREGKGGNPAAASDLVRWISGVIGDVPIAYVDADMPMLTGNKSI
KSEEVYAGHPVLLNMGSALVKDGVNLPMENVAFNTDIINFTGECKDRSIAIKRIAQSLIGNYLHVTERIS
KSGNPELKRLGLMPGYHQLLKDCEENNNKLSLPMLRKALTQAHSNLSSYVRFIGVQRFAEMVGAPEDAPL
FQEALQQGNTIVLTNALVAYLVHGMDNVSRLNSSEKENLIKKYLGTQLSLLYKPLVMEFSGPCAVTREIL
PLLPTGEPTRYIENLKQPDAQILRVLQTHACVAGKTNFTSDNIPNWITSSEEVERTQSLRTDGLSWMPSE
QARLSK
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Nucleotide Sequence: 1911 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c3239802-3237892 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGAGCGAACAATATTGGCGTTTCAAATTGATGACTGAGGGTGGATGTAATCAAAATGAAGCAACCAGAC
TTATAACCGTTTTAAAACGTAAGTTGAAGCCATTCCCTGAGGAGTCAATCAATAAATTATTCGAAAACGA
TAATTTTTGTAATCGACTTTCCTCTTACATGGCATATGGATTTGGGGCAGCAGAAGAATGGATAAAAAAG
CAACAAATATTAAGTAATATCCAACCGTTAACTTCTGAACAAAGAGTTGATATCACACCAGAGAAGGATA
CGGTTAGTGATAATAAGCCGAATATCTTTGGCGCTGCAATTACATTTGGAAAATCACCTGTAGTGAAGCT
TCTTAAGCAAAATGCCAGAGAAATATGCGAATCAATTTTAATGGATGAACCAAATCTAAAACAGGTCGAA
TACATCTTCAGGTTATTGGCACTTCAAGTCCAAGAGACTTATTCAGGTGAGCAAGCTGAAAAGTTATACG
AATGTATTCGGGATAAAAAGCCAATACCCTCAAAATTTGAGGAAATATTGCTCCCAATAGTGAATCGTAT
TAAAGAGAACCATACAGAAATCCTTAATGAATCTAAAAGGAATCACTTGGGAGTAACTATTCAGTTAAAC
GATCCCTATAGTTTTTCAACAAAAAATTCTTTTTGTATTTGGTTTAGTAATAATCCTAACAGTGCCATGC
CAAAAAAAATTAAGGATATTTTGGAAGAAAGAGCCAAACAAAATGCACCAGGAGTAACAAAATTAGTTTA
TAGCCGAGCTTGTTTGACCAAGAAAGAAAATACTAATTTTGTTCAGTGGGCAAAAGAGAATGGTATTACA
TTATTAGATTTTGATGAGTTAAAATGTCAGGGCGAGGATTTAGAATTATGGAATTTGGCACAGGCCGAGT
TAAAGGCGATGCGTGAAGGTAAAGGAGGGAATCCTGCTGCTGCCTCTGATCTGGTGCGATGGATATCAGG
TGTCATAGGAGATGTTCCCATAGCCTACGTTGATGCCGATATGCCAATGCTTACTGGTAATAAAAGCATT
AAGTCTGAAGAGGTTTATGCGGGACATCCTGTGCTATTAAATATGGGATCTGCATTGGTTAAAGATGGGG
TTAATTTGCCCATGGAAAATGTTGCATTTAATACGGATATTATCAATTTCACTGGTGAATGTAAGGATAG
AAGCATTGCCATTAAACGGATTGCTCAATCGCTGATTGGCAACTACCTCCATGTTACAGAGCGGATTTCT
AAGAGTGGTAATCCAGAACTCAAGAGACTTGGCCTGATGCCAGGCTACCATCAGCTTTTGAAAGATTGTG
AAGAAAACAACAACAAGTTGTCTCTACCGATGTTACGAAAAGCATTGACACAGGCTCACAGTAATTTGAG
TTCTTATGTAAGATTTATTGGCGTACAGCGATTTGCTGAAATGGTTGGTGCGCCAGAGGATGCCCCATTA
TTCCAGGAAGCATTACAACAAGGTAATACCATTGTCTTAACAAATGCATTAGTGGCTTATTTAGTTCATG
GTATGGATAACGTATCAAGATTAAACTCATCTGAAAAAGAGAATTTAATTAAGAAATATTTGGGCACTCA
GCTTTCTTTATTATACAAACCCTTGGTGATGGAGTTCTCTGGGCCCTGTGCAGTAACTCGTGAAATACTA
CCGCTATTACCTACTGGTGAACCAACACGTTATATTGAAAACCTCAAACAGCCTGATGCACAAATTTTAC
GTGTATTGCAAACGCATGCCTGTGTGGCTGGGAAGACTAATTTTACTTCCGATAATATTCCAAATTGGAT
AACTTCCTCAGAAGAAGTTGAGCGTACACAATCCCTGCGAACGGATGGCTTGAGTTGGATGCCTAGTGAG
CAAGCACGATTATCAAAATAA

Reference
(1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890]
(2) Tzivelekidis T; Jank T; Pohl C; Schlosser A; Rospert S; Knudsen CR; Rodnina MV; Belyi Y; Aktories K (2011). Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. PLoS One. 6(12):e29525. [PudMed:22216304] experimental
(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(4) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(5) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206] experimental
(6) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature