SecReT4
Effector Protein ID: 52843026
T4SS name [ID]Dot/Icm [5]
Gene symbollegU2
Locus taglpg2830
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]3201113..3201853 [-]
ProductUBOX-containing protein
Effector typeProtein
DescriptonLubX/legU2
T4CP requirementT4CP Depedent
Target/EffectionLubX has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009)
UniProt IDQ5ZRQ0
KEGG IDlpn:lpg2830
PDB IDNA
Domain hit(s) vs Pfam U-box [PF04564], Evalue: 5e-26, Aligned region: 38..107
U-box [PF04564], Evalue: 5e-26, Aligned region: 132..195
zf-RING_LisH [PF13445], Evalue: 2.3e-10, Aligned region: 132..167
Protein Sequence: 246 a.a.     [Download]
>gi|52843026|ref|YP_096825.1| UBOX-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MGYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKW
LETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPI
SKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREMQKNQI
QPSVSSGFGFFSLNFLTSWLWGTEEKKEKTSSDMTY
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Nucleotide Sequence: 741 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c3201853-3201113 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
TTGGGGTATAGAATAGAAATGGCGACACGAAATCCTTTTGATATTGATCATAAAAGTAAATACTTAAGAG
AAGCAGCATTAGAGGCCAATTTATCTCATCCAGAAACAACACCAACAATGCTGACTTGCCCTATTGACAG
CGGATTTCTAAAAGATCCCGTGATCACACCAGAAGGTTTTGTTTATAATAAATCCTCTATTTTAAAATGG
TTAGAAACGAAAAAAGAAGACCCACAAAGCCGTAAACCCTTAACGGCTAAAGATTTGCAACCATTCCCCG
AGTTATTGATTATAGTCAATAGATTTGTTGAGACACAAACGAACTATGAAAAATTAAAAAACAGATTAGT
GCAAAATGCTCGGGTTGCTGCACGCCAAAAAGAATACACTGAAATTCCGGATATATTTCTTTGCCCAATA
AGTAAAACGCTTATCAAAACACCTGTCATTACTGCCCAAGGGAAAGTATATGATCAAGAAGCATTAAGTA
ACTTTCTTATCGCAACGGGTAATAAAGATGAAACAGGCAAAAAATTATCCATTGATGATGTAGTGGTGTT
TGATGAACTCTATCAACAGATAAAAGTTTATAATTTTTACCGCAAACGCGAAATGCAAAAAAATCAAATT
CAACCTTCAGTAAGTAGTGGTTTTGGCTTTTTTAGCTTGAATTTTCTCACCTCATGGTTATGGGGAACTG
AGGAGAAAAAAGAAAAGACATCATCTGATATGACGTACTAA

Reference
(1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890]
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(4) Kubori T; Hyakutake A; Nagai H (2008). Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol. 67(6):1307-19. [PudMed:18284575] experimental
 
experimental experimental literature
in_silico in silico analysis literature