SecReT4
Effector Protein ID: 52842371
T4SS name [ID]Dot/Icm [5]
Gene symbol-
Locus taglpg2157
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2416693..2421213 [+]
ProductSid related protein-like
Effector typeProtein
DescriptonLaiA/SdeA
T4CP requirementT4CP Depedent
Target/EffectionAn integrin-like protein involved in adhesion to and invasion of human lung alveolar epithelial cells. (Chang et al. 2005)
UniProt IDQ5ZTK4
KEGG IDlpn:lpg2157
PDB IDNA
Domain hit(s) vs Pfam SidE [PF12252], Evalue: 0, Aligned region: 8..1446
Protein Sequence: 1506 a.a.     [Download]
>gi|52842371|ref|YP_096170.1| Sid related protein-like [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MSLGEAIMPKYVEGVELTQEGMHAIFARMGYGDITSGSIYNGVPTIDTGALNRQGFMPVLTGVGPHRDSG
HWIMLIKGPGNQYYLFDPLGKTSGEGYQNILAAQLPMGSTLSVIPNGSGLNMGLCGYWVASAGLRAHQAL
NQHNPPTLLNVGQTITNEMRNELDHDGYRKITGWLRAVADEFPEGDPQLDGKALRENTEKDLKIEIPTLV
LPGKDTSPKEMSVKPTAPQDKSVPVWNGFSLYTDDTVKAAAQYAYDNYLGKPYTGSVESAPANFGGRMVY
RQHHGLSHTLRTMAYAELIVEEARKAKLRGETLGKFKDGRTIADVTPQELKKIMIAQAFFVAGRDDEASD
AKNYQKYHEQSRDAFLKYVKDNESTLIPDVFKDQEDVNFYARVIEDKSHDWESTPAHVLINQGHMVDLVR
VKQPPESFLQRYFSSMQRWIGSQATEAVFGIQRQFFHATYEVVAGFDSDNKEPHLVVSGLGRYVIGEDGQ
PIREAPKKGQKEGDLKVFPQTYKLKENERLMRVDEFLKLPEIQNTFPGSGKHLQGGMPGMNEMDYWNRLN
SLNRARCENDVDFCLKQLQTAHDKAKIEPIKQAFQSSKGKERRQPNVDEIAAARIIQQILANPDCIHDDH
VLINGQKLEQQFFRDLLAKCEMAVVGSLLNDTDIGNIDTLMRHEKDTEFHSTNPEAVPVKIGEYWINDQR
INNSSGNITQKKHDLIFLMQNDAWYFSRVNAIAQNRDKGSTFKEVLITTLMTPLTSKALVDTSQAKPPTR
LFRGLNLSEEFTKGLIDQANAMIANTTERLFTDHSPEAFKQIKLNDLSKMSGRTNASTTTEIKLVKETWD
SNVIFEMLDPDGLLHSKQVGRHGEGTESEFSVYLPEDVALVPVKVTLDGKTQKGENRYVFTFVAVKSPDF
TPRHESGYAVEPFLRMQAAKLAEVKSSIEKAQRAPDLETIFNLQNEVEAVQYSHLSTGYKNFLKNTVGPV
LENSLSGLMESDTDTLSKALAAFPSDTQWSAFNFEEARQAKRQMDAIKQMVGNKVVLDALTQCQDALEKQ
NIAGALDALKKIPSEKEMGTIRRELREQIQSARQELESLQRAVVTPVVTDEKKVRERYDALIENTSKKIT
ELETGKLPNLDAVKKGISNLSNLKQEVTVLRNEKIRMHVGTDKVDFSDVEKLEQQIQVIDTKLADAYLLE
VTKQISALDNTKPKNQTELKTKIAAFLDRTTDIEMLRNERIKKHGSSKDPLDLSDLDKLSGSLQRINQSL
VSDLITTIRVSINQMEAKTFHEQEKEIQQNFELLAKLEKTLDKSKTSEKLREDIPKLNDLLVAKQKAYPQ
MVQMQLKSEVFVTQLREVCQANHDDLDKTRNARLRELDRLDREAGITRMVGNLIWGLTNKVGLTTDERLD
IRTKQQSLARFKNELFNDKIDTDQLISNLARKRPSELQEGLGISTDNAMELHLLLTELAGKTTSPDELEE
RMKAIDDISTKIGREPEHLKFVMVEEDESNKKTIGF
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Nucleotide Sequence: 4521 bp     [Download]
>gi|52840256|ref|NC_002942.5|:2416693-2421213 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATCAGTTTGGGAGAAGCCATAATGCCTAAGTATGTCGAAGGGGTAGAACTAACTCAAGAAGGTATGCATG
CTATTTTTGCACGCATGGGGTATGGAGATATTACCAGCGGTAGCATATACAACGGAGTGCCAACTATTGA
CACAGGTGCGCTAAACAGGCAAGGTTTTATGCCCGTGTTAACCGGGGTAGGACCACACAGAGACTCCGGC
CACTGGATTATGTTAATCAAAGGTCCTGGCAACCAATACTACCTCTTTGACCCATTAGGCAAAACATCAG
GTGAAGGCTATCAAAATATTTTAGCAGCCCAATTACCAATGGGGTCTACCCTTTCTGTTATTCCCAATGG
TTCCGGTTTGAATATGGGATTATGCGGCTACTGGGTCGCCTCTGCTGGTTTAAGAGCACACCAGGCATTA
AATCAACATAATCCCCCTACTTTGTTAAATGTGGGACAAACCATTACCAATGAAATGCGTAACGAACTCG
ATCATGACGGTTATCGAAAAATTACCGGATGGTTACGTGCTGTTGCTGATGAATTCCCTGAAGGTGACCC
ACAATTAGATGGGAAAGCATTAAGAGAAAACACTGAAAAAGATTTAAAAATAGAAATTCCTACACTGGTT
CTTCCTGGAAAAGATACCTCCCCTAAAGAAATGTCTGTTAAACCCACTGCACCACAAGATAAATCTGTGC
CTGTTTGGAATGGGTTTTCATTATATACTGATGATACCGTTAAAGCCGCGGCACAATACGCCTATGACAA
CTATCTGGGCAAACCGTATACCGGATCAGTTGAATCAGCACCTGCGAATTTTGGCGGTCGAATGGTGTAC
AGACAACATCATGGACTTTCCCATACTTTACGGACCATGGCTTATGCGGAATTGATTGTTGAAGAAGCAC
GTAAAGCTAAATTACGGGGTGAAACATTAGGGAAATTCAAAGACGGACGTACTATTGCTGACGTTACCCC
TCAAGAACTAAAAAAAATCATGATTGCCCAGGCATTTTTTGTAGCTGGACGTGATGATGAAGCATCCGAT
GCCAAGAACTACCAAAAATATCATGAACAAAGCCGGGATGCTTTCTTAAAATATGTGAAAGACAATGAAT
CCACTTTGATTCCTGATGTTTTCAAAGATCAGGAAGATGTCAATTTTTATGCCCGAGTGATTGAAGATAA
AAGTCATGATTGGGAATCAACCCCAGCCCATGTGCTAATTAACCAGGGCCATATGGTCGATTTGGTACGG
GTCAAGCAACCCCCTGAATCATTCTTACAACGCTATTTCAGTTCCATGCAACGCTGGATAGGTTCACAGG
CAACGGAAGCTGTTTTTGGAATACAAAGACAGTTTTTCCATGCTACCTATGAAGTAGTCGCAGGTTTTGA
CTCCGATAACAAAGAACCTCATTTGGTTGTTTCTGGTTTAGGTCGTTATGTCATCGGTGAAGATGGTCAA
CCTATCCGAGAAGCTCCGAAAAAAGGACAGAAAGAAGGAGATTTAAAAGTTTTCCCTCAAACTTATAAAT
TAAAAGAAAATGAGCGTCTTATGCGCGTCGATGAATTTTTAAAACTTCCTGAAATACAAAATACCTTCCC
TGGTTCTGGCAAACATTTACAAGGTGGAATGCCAGGTATGAATGAAATGGATTATTGGAATCGACTGAAC
TCTTTAAACAGAGCACGATGCGAAAACGATGTTGATTTTTGTTTGAAACAATTACAAACAGCCCATGACA
AGGCGAAAATTGAGCCTATTAAACAAGCTTTTCAATCCAGTAAAGGGAAAGAAAGAAGACAACCTAATGT
CGATGAAATTGCTGCTGCCCGCATCATTCAGCAAATCTTGGCCAATCCTGATTGCATCCATGATGATCAT
GTGCTCATCAATGGCCAGAAACTGGAACAACAATTCTTCCGTGACTTGTTAGCGAAATGCGAGATGGCTG
TTGTAGGCTCACTCCTCAATGACACCGACATAGGAAACATTGATACTTTAATGCGACATGAAAAAGACAC
TGAGTTTCATTCTACCAATCCTGAAGCAGTTCCGGTGAAAATTGGAGAATATTGGATTAATGACCAAAGA
ATTAATAATAGTAGTGGCAACATCACCCAAAAGAAACACGATCTAATTTTCCTCATGCAAAATGATGCGT
GGTATTTTAGCCGAGTCAATGCCATCGCCCAAAACCGGGATAAAGGCTCTACTTTCAAGGAGGTGTTGAT
TACTACTTTAATGACGCCTTTGACTAGTAAAGCACTAGTGGATACCTCGCAAGCCAAGCCCCCTACAAGA
CTATTTCGTGGATTAAACCTGTCAGAAGAGTTTACCAAGGGATTAATTGATCAAGCGAATGCAATGATTG
CCAATACGACAGAGCGTCTTTTCACCGATCATTCACCAGAAGCCTTCAAACAAATCAAGTTAAATGATTT
AAGTAAAATGTCCGGCAGAACCAATGCCAGTACAACCACGGAGATTAAGCTTGTAAAAGAAACCTGGGAC
TCCAATGTCATCTTTGAAATGCTTGACCCGGATGGTTTGCTGCATTCCAAGCAAGTAGGACGCCATGGCG
AAGGCACCGAAAGTGAATTCTCCGTTTATTTGCCGGAGGATGTTGCCCTGGTCCCAGTCAAGGTCACCCT
TGATGGTAAAACGCAAAAAGGGGAAAATCGATATGTCTTTACCTTTGTTGCCGTAAAAAGCCCTGACTTT
ACACCACGTCATGAAAGCGGCTATGCGGTTGAACCGTTTTTAAGAATGCAAGCCGCAAAGTTAGCCGAAG
TCAAAAGCTCTATTGAAAAAGCCCAGAGAGCACCTGACCTTGAGACAATTTTCAATTTACAAAACGAAGT
AGAAGCAGTGCAATACTCACACTTATCGACGGGTTACAAAAATTTTCTAAAAAACACCGTTGGTCCTGTT
TTAGAAAATAGTCTTAGTGGACTCATGGAGAGTGACACGGACACTTTAAGTAAAGCATTAGCAGCATTCC
CATCCGATACACAATGGTCAGCCTTCAATTTTGAAGAAGCAAGGCAAGCCAAAAGACAGATGGATGCCAT
TAAGCAAATGGTTGGAAATAAAGTGGTGCTTGACGCCTTGACTCAATGCCAGGACGCGCTGGAAAAGCAA
AATATCGCTGGCGCACTGGATGCTCTCAAAAAAATCCCGTCCGAAAAAGAGATGGGTACAATTAGAAGAG
AGCTAAGAGAACAAATCCAAAGCGCCAGGCAAGAACTGGAATCATTGCAGCGTGCTGTTGTTACCCCTGT
AGTAACCGATGAAAAGAAAGTAAGAGAACGCTATGATGCCCTGATAGAAAACACATCGAAGAAAATTACT
GAACTTGAAACAGGGAAATTACCCAATCTTGATGCTGTCAAGAAAGGCATATCTAACTTGAGCAACCTGA
AACAAGAAGTAACCGTATTACGTAATGAAAAAATACGGATGCACGTTGGAACTGATAAAGTTGATTTTTC
AGATGTTGAAAAACTGGAACAACAAATACAGGTTATCGATACCAAATTAGCCGATGCTTATTTACTTGAA
GTAACCAAACAAATTTCAGCGCTTGACAATACAAAACCCAAAAATCAGACTGAATTGAAAACAAAAATAG
CAGCATTTCTTGACAGAACCACTGATATTGAAATGTTGCGTAATGAGCGAATCAAAAAACACGGTTCATC
GAAAGATCCACTGGATCTGTCTGATTTGGATAAATTAAGCGGCAGCTTACAGCGCATTAATCAATCCCTG
GTTTCAGATTTGATAACAACCATCCGTGTGTCCATCAATCAAATGGAAGCGAAAACTTTTCACGAACAGG
AAAAGGAAATACAACAAAATTTCGAGTTACTCGCAAAACTCGAAAAAACATTGGATAAGTCAAAGACATC
AGAAAAACTAAGGGAGGATATTCCCAAACTTAATGATTTGCTGGTTGCAAAACAAAAAGCCTACCCTCAA
ATGGTACAAATGCAACTCAAGAGCGAAGTCTTCGTTACCCAATTACGTGAGGTATGTCAAGCTAACCATG
ACGATCTGGATAAAACAAGAAATGCAAGATTACGAGAACTGGATCGGCTGGACAGAGAAGCTGGAATAAC
AAGAATGGTGGGTAATCTAATCTGGGGTCTTACCAACAAAGTAGGTTTAACCACAGACGAACGACTTGAC
ATCAGGACTAAACAGCAATCGCTTGCACGATTCAAAAATGAATTATTTAATGACAAGATTGATACGGATC
AGCTAATCTCTAATTTGGCAAGGAAAAGACCTTCTGAACTGCAAGAAGGATTGGGAATATCTACAGACAA
TGCGATGGAGTTACATTTACTGTTAACTGAGTTAGCGGGTAAAACAACTTCTCCAGATGAACTGGAAGAA
AGAATGAAAGCAATCGATGACATTTCCACCAAGATAGGTAGAGAGCCTGAGCATTTGAAATTTGTCATGG
TTGAAGAAGATGAATCCAATAAAAAAACTATAGGATTTTAA

Reference
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(3) Bardill JP; Miller JL; Vogel JP (2005). IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol. 56(1):90-103. [PudMed:15773981] experimental
 
experimental experimental literature
in_silico in silico analysis literature